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Mitofusin-2 Expression Is Implicated in Cervical Cancer Pathogenesis

Authors
 Sung Yong Ahn  ;  Chengri Li  ;  Xianglan Zhang  ;  Young-Min Hyun 
Citation
 Anticancer Research, Vol.38(6) : 3419-3426, 2018 
Journal Title
 Anticancer Research 
ISSN
 0250-7005 
Issue Date
2018
MeSH
Adult ; Aged ; Tumor/biosynthesis Biomarkers ; Squamous Cell/*metabolism/pathology Carcinoma ; Cervical Intraepithelial Neoplasia/*metabolism/pathology ; Disease Progression ; Female ; GTP Phosphohydrolases/*biosynthesis ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Middle Aged ; Mitochondrial Proteins/*biosynthesis ; Neoplasm Staging ; Uterine Cervical Neoplasms/*metabolism/pathology ; Young Adult
Keywords
Mitofusin-2 ; biomarker ; cervical cancer pathogenesis ; cervical carcinogenesis ; cervical intraepithelial neoplasia ; oncogene
Abstract
BACKGROUND/AIM: It remains unclear whether mitofusin-2 (MFN2) functions as a tumour suppressor or oncogene in cancer progression. In this study we, therefore, aimed to investigate the effect of MFN2 on the pathogenesis of cervical cancer. MATERIALS AND METHODS: MFN2 expression was detected in seven healthy cervical, 64 cervical intraepithelial neoplasia (CIN), and 120 cervical squamous cell carcinoma (SCC) tissues by immunohistochemistry. Moreover, biological function of MFN2 in cervical cancer was investigated in vitro. RESULTS: MFN2 levels exhibited a tendency to gradually increase from healthy cervical tissue to CIN to SCC. Moreover, MFN2 expression was significantly associated with higher T-stage (p=0.008) and lymph node metastasis (p<0.001). The proliferative, migratory, and invasive abilities of MFN2-knockdown cells were significantly lower (p<0.001, p<0.001, and p<0.001, respectively) than control cells. CONCLUSION: MFN2 may be involved in cervical cancer pathogenesis as an oncogene and might serve as a biomarker of cervical SCC.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162472
Full Text
http://ar.iiarjournals.org/content/38/6/3419
DOI
10.21873/anticanres.12610
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
Yonsei Authors
안성용(Ahn, Sung Yong) ORCID logo https://orcid.org/0000-0002-6029-1853
장향란(Zhang, Xiang Lan)
현영민(Hyun, Young-Min) ORCID logo https://orcid.org/0000-0002-0567-2039
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