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Preliminary evidence of altered gray matter volume in subjects with internet gaming disorder: associations with history of childhood attention-deficit/hyperactivity disorder symptoms

Authors
 Deokjong Lee  ;  Kee Namkoong  ;  Junghan Lee  ;  Young-Chul Jung 
Citation
 BRAIN IMAGING AND BEHAVIOR, Vol.0 : 1-9, 2018 
Journal Title
 BRAIN IMAGING AND BEHAVIOR 
ISSN
 1931-7557 
Issue Date
2018
Keywords
Attention-deficit/hyperactivity disorder ; Gray matter volume ; Internet gaming disorder ; Voxel-based morphometry
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is commonly comorbid with Internet gaming disorder (IGD). Although childhood ADHD symptoms may decline during late brain maturation, structural alterations in some brain areas may persist into adulthood. This study investigated whether young adults with IGD and a history of childhood ADHD symptoms had gray matter volume (GMV) alterations that were distinct from subjects without a history of childhood ADHD. As an exploratory investigation, we conducted a whole-brain voxel-based morphometry with the diffeomorphic anatomical registration using an exponentiated Lie algebra algorithm and applied an uncorrected threshold at the voxel level for multiple comparisons. GMVs of IGD subjects with a history of childhood ADHD (IGDADHD+ group; n = 20; 24.5 +/- 2.5 years) were compared to those of subjects without a history of childhood ADHD (IGDADHD- group; n = 20; 23.9 +/- 2.5 years) and controls (n = 20; 22.7 +/- 2.4 years). Compared with controls, both IGD groups had a smaller GMV in the right anterior cingulate cortex, the left inferior frontal gyrus, and the left insula, yet had a larger GMV in the right angular gyrus. The IGDADHD+ group had a larger GMV in the right precuneus than the IGDADHD- group and controls. When controlling for other comorbid psychiatric symptoms, the IGDADHD+ group also had a smaller GMV in the right inferior frontal gyrus. In conclusion, we found that young adults with IGD and a history of childhood ADHD symptoms had characteristic GMV alterations, which may be linked with their manifestation of childhood ADHD.
Full Text
https://link.springer.com/article/10.1007%2Fs11682-018-9872-6
DOI
10.1007/s11682-018-9872-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162450
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