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Impact of white matter hyperintensities on the prognosis of cryptogenic stroke patients

DC Field Value Language
dc.contributor.author김경섭-
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author안성수-
dc.contributor.author유준상-
dc.contributor.author이혜선-
dc.contributor.author허지회-
dc.date.accessioned2018-08-28T17:14:09Z-
dc.date.available2018-08-28T17:14:09Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162392-
dc.description.abstractBACKGROUND: To our knowledge, little is known regarding whether white matter hyperintensities (WMH) affect the prognosis of cryptogenic stroke (CS) patients. Understanding this association may be helpful with expecting the prognosis of CS patients. METHODS: This retrospective observational study enrolled consecutive CS patients who underwent brain MRI and comprehensive cardiac evaluation. Severe WMH was defined as Fazekas' score >/=3. We defined poor functional outcome as modified Rankin Scale score >/=3 at 3 months. Long-term mortality and causes of death were identified using national death certificates and assessed by Kaplan-Meier method and regression analysis model. RESULTS: Among 2732 patients with first-ever ischemic stroke, 599 (21.9%) patients were classified as having CS. After exclusions, 235 patients were enrolled and followed up for a median of 7.7 years (IQR, 6.7-9.0). Severe WMH were found in 81 (34.5%) patients. After adjustments, severe WMH were an independent predictor for poor functional outcomes at 3 months (OR 5.25, 95% CI, 2.07-13.31). Subgroup analysis showed that severe WMH were an independent predictor for long-term mortality only in younger patients (age < 65) (HR 3.11, 95% CI, 1.29-7.50), but not in older patients (HR 1.19, 95% CI, 0.63-2.23). CONCLUSIONS: Severe WMH were independently associated with short-term functional outcomes in CS patients and independently associated with long-term mortality in younger CS patients. Grading WMH is of value in predicting prognosis of CS patients with young age.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuroimaging/*methods-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRegression Analysis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStroke/*physiopathology-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHX-Ray Computed Tomography-
dc.subject.MESHWhite Matter/*physiopathology-
dc.titleImpact of white matter hyperintensities on the prognosis of cryptogenic stroke patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorSeong Ho Jeong-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorMinyoul Baik-
dc.contributor.googleauthorKi Hoon Kim-
dc.contributor.googleauthorJoonSang Yoo-
dc.contributor.googleauthorKyoungsub Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJimin Ha-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorHyo Suk Nam-
dc.identifier.doi10.1371/journal.pone.0196014-
dc.contributor.localIdA05088-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA02234-
dc.contributor.localIdA02513-
dc.contributor.localIdA03312-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid29702667-
dc.contributor.alternativeNameKim, Kyoung Sub-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameYoo, Joon Sang-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKim, Kyoung Sub-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorYoo, Joon Sang-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.citation.volume13-
dc.citation.number4-
dc.citation.startPagee0196014-
dc.identifier.bibliographicCitationPLOS ONE, Vol.13(4) : e0196014, 2018-
dc.identifier.rimsid59976-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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