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Predictors of adverse pathologic features after radical prostatectomy in low-risk prostate cancer

Authors
 Jae Won Park  ;  Dong Hoon Koh  ;  Won Sik Jang  ;  Kang Su Cho  ;  Won Sik Ham  ;  Koon Ho Rha  ;  Sung Joon Hong  ;  Young Deuk Choi 
Citation
 BMC CANCER, Vol.18(1) : 545, 2018 
Journal Title
BMC CANCER
Issue Date
2018
Keywords
Adverse pathologic features ; Low-risk prostate cancer ; Needle biopsy ; Radical prostatectomy
Abstract
BACKGROUND: Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous related studies had utilized outdated staging criteria or small sample cohorts. In this study, we analyzed predictors of APFs after RP in low-risk PC using classification under the current criteria. MATERIALS AND METHODS: We retrospectively reviewed medical records of 546 low-risk PC patients who had undergone RP. Low-risk PC was defined as PC with clinical T1-T2a, Gleason score 4.5 ng/mL and number of positive cores > 2 in low-risk PC were significantly associated with APFs, and suggested as cut-off values for predicting APFs. CONCLUSIONS: PSA > 4.5 ng/mL and number of positive cores > 2 in low-risk PC were associated with presence of APFs and patients with such records should be considered carefully to provide active surveillance.
Files in This Item:
T201801482.pdf Download
DOI
10.1186/s12885-018-4416-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Dong Hoon(고동훈)
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Park, Jae Won(박재원)
Jang, Won Sik(장원식) ORCID logo https://orcid.org/0000-0002-9082-0381
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162380
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