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EW-7197 eluting nano-fiber covered self-expandable metallic stent to prevent granulation tissue formation in a canine urethral model

 Kichang Han  ;  Jung-Hoon Park  ;  Su-Geun Yang  ;  Deok Hee Lee  ;  Jiaywei Tsauo  ;  Kun Yung Kim  ;  Min Tae Kim  ;  Sung Gwon Gang  ;  Dae-Kee Kim  ;  Dong-Hyun Kim  ;  Ho-Young Song 
 PLOS ONE, Vol.13(2) : e0192430, 2018 
Journal Title
Issue Date
Aniline Compounds/*administration & dosage ; Animals ; Dogs ; *Drug-Eluting Stents ; Granulation Tissue/*pathology ; Male ; Animal *Models ; *Nanofibers ; Triazoles/*administration & dosage ; Urethra/*pathology
PURPOSE: To evaluate an EW-7197-eluting nanofiber-covered stent (NFCS) for suppressing granulation tissue formation after stent placement in a canine urethral model. MATERIALS AND METHODS: All experiments were approved by the committee of animal research. A total of 12 NFCSs were placed in the proximal and distal urethras of six dogs. Dogs were divided into two groups with 3 dogs each. The control stent (CS) group received NFCSs and the drug stent (DS) group received EW-7197 (1000 mug)-eluting NFCSs. All dogs were sacrificed 8 weeks after stent placement Histologic findings of the stented urethra were compared using the Mann-Whitney U test. RESULTS: Stent placement was technically successful in all dogs without procedure-related complications. On urethrographic analysis, the mean luminal diameter was significantly larger in the DS group than in the CS group at 4 and 8 weeks after stent placement (all p < 0.001). On histological examination, mean thicknesses of the papillary projection, thickness of submucosal fibrosis, number of epithelial layers, and degree of collagen deposition were significantly lower in the DS group than in the CS group (all p < 0.001), whereas the mean degree of inflammatory cell infiltration was not significantly different (p > 0.05). CONCLUSION: The EW-7197-eluting NFCS is effective and safe for suppressing granulation tissue formation after stent placement in a canine urethral model.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Han, Ki Chang(한기창) ORCID logo https://orcid.org/0000-0002-9701-9757
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