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HSP27 inhibitor attenuates radiation-induced pulmonary inflammation

 Jee-Youn Kim  ;  Yong-Min An  ;  Byeong Rok Yoo  ;  Jin-Mo Kim  ;  Song Yee Han  ;  Younghwa Na  ;  Yun-Sil Lee  ;  Jaeho Cho 
 SCIENTIFIC REPORTS, Vol.8(1) : 4189, 2018 
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Radiation therapy has been used to treat over 70% of thoracic cancer; however, the method usually causes radiation pneumonitis. In the current study, we investigated the radioprotective effects of HSP27 inhibitor (J2) on radiation-induced lung inflammation in comparison to amifostine. In gross and histological findings, J2 treatment significantly inhibited immune cell infiltration in lung tissue, revealing anti-inflammatory potential of J2. Normal lung volume, evaluated by micro-CT analysis, in J2-treated mice was higher compared to that in irradiated mice. J2-treated mice reversed radiation-induced respiratory distress. However, amifostine did not show significant radioprotective effects in comparison to that of J2. In HSP27 transgenic mice, we observed increased immune cells recruitment and decreased volume of normal lung compared to wild type mice. Increased ROS production and oxidative stress after IR were down-regulated by J2 treatment, demonstrating antioxidant property of J2. The entire data of this study collectively showed that J2 may be an effective therapeutic agent for radiation-induced lung injury.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Yeon(김지연)
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
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