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Functionalized Magnetic PLGA Nanospheres for Targeting and Bioimaging of Breast Cancer

Authors
 Seung-Jun Lee  ;  Hee-Jin Kim  ;  Yong-Min Huh  ;  Il Won Kim  ;  Jae Hyun Jeong  ;  Jin-Chul Kim  ;  Jong-Duk Kim 
Citation
 JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Vol.18(3) : 1542-1547, 2018 
Journal Title
 JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 
ISSN
 1533-4880 
Issue Date
2018
MeSH
Breast Neoplasms/*diagnostic imaging ; Tumor Cell Line ; Contrast Media ; Humans ; *Lactic Acid ; *Magnetic Resonance Imaging ; *Magnetite Nanoparticles ; Nanospheres ; *Polyglycolic Acid
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are actively used as highly sensitive imaging probes to provide contrast in MRI. In this study, we propose the use of SPIONs encapsulated with antibody-conjugated poly(lactic-co-glycolic acid) (PLGA) as a potent theragnostic agent. The SPIONs were synthesized by a chemical co-precipitation method of ferric and ferrous ions, and subsequently encapsulated with PLGA by using an emulsification-diffusion method. Herceptin was chemically conjugated to the SPION-encapsulating PLGA nanoparticles to target the human epidermal growth factor receptor 2 (Her2/neu) overexpressing breast cancers. FACS and MR molecular imaging revealed that the Her2/neu overexpressing cell line showed a stronger contrast enhancement than the Her2/neu non-expressing cell lines, and the signal intensity of in vivo MR imaging decreased as the concentration of Herceptin increased. This strategy of encapsulating SPIONs with PLGA will be highly useful in functionalizing magnetic nanoparticles and improving the diagnostic and therapeutic efficacy of a wide array of cancer treatments.
Full Text
http://www.ingentaconnect.com/content/asp/jnn/2018/00000018/00000003/art00004
DOI
10.1166/jnn.2018.14220
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162203
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