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Inflachromene inhibits autophagy through modulation of Beclin 1 activity

Authors
 Young Hun Kim  ;  Man Sup Kwak  ;  Jae Min Shin  ;  Ria Aryani Hayuningtyas  ;  Ji Eun Choi  ;  Jeon-Soo Shin 
Citation
 Journal of Cell Science, Vol.131(4) : jcs211201, 2018 
Journal Title
 Journal of Cell Science 
ISSN
 0021-9533 
Issue Date
2018
Keywords
Autophagy ; Beclin 1 ; Inflachromene ; RNF216
Abstract
Autophagy is a central intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles, and regulation of autophagy is essential for homeostasis. HMGB1 is an important sepsis mediator when secreted and also functions as an inducer of autophagy by binding to Beclin 1. In this study, we studied the effect of inflachromene (ICM), a novel HMGB1 secretion inhibitor, on autophagy. ICM inhibited autophagy by inhibiting nucleocytoplasmic translocation of HMGB1 and by increasing Beclin 1 ubiquitylation for degradation by enhancing the interaction between Beclin 1 and E3 ubiquitin ligase RNF216. These data suggest that ICM could be used as a potential autophagy suppressor.
Full Text
http://jcs.biologists.org/content/131/4/jcs211201
DOI
10.1242/jcs.211201
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Man Sup(곽만섭) ORCID logo https://orcid.org/0000-0002-3989-3016
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162161
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