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The Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure

 Jin Joo Park  ;  Sun-Hwa Kim  ;  Il-Young Oh  ;  Dong-Ju Choi  ;  Hyun-Ah Park  ;  Hyun-Jai Cho  ;  Hae-Young Lee  ;  Jae-Yeong Cho  ;  Kye Hun Kim  ;  Jung-Woo Son  ;  Byung-Su Yoo  ;  Jaewon Oh  ;  Seok-Min Kang  ;  Sang Hong Baek  ;  Ga Yeon Lee  ;  Jin Oh Choi  ;  Eun-Seok Jeon  ;  Sang Eun Lee  ;  Jae-Joong Kim  ;  Ju-Hee Lee  ;  Myeong-Chan Cho  ;  Se Yong Jang  ;  Shung Chull Chae  ;  Byung-Hee Oh 
 JACC-HEART FAILURE, Vol.6(4) : 286-294, 2018 
Journal Title
Issue Date
acute heart failure ; door-to-diuretic time ; outcomes
OBJECTIVES: This study sought to examine the impact of door-to-diuretic (D2D) time on mortality in patients with acute heart failure (AHF) who were presenting to an emergency department (ED). BACKGROUND: Most patients with AHF present with congestion. Early decongestion with diuretic agents could improve their clinical outcomes. METHODS: The Korea Acute Heart Failure registry enrolled 5,625 consecutive patients hospitalized for AHF. For this analysis, the study included patients who received intravenous diuretic agents within 24 h after ED arrival. Early and delayed groups were defined as D2D time 60 min, respectively. The primary outcomes were in-hospital death and post-discharge death at 1 month and 1 year on the basis of D2D time. RESULTS: A total of 2,761 patients met the inclusion criteria. The median D2D time was 128 min (interquartile range: 63 to 243 min), and 663 (24%) patients belonged to the early group. The baseline characteristics were similar between the groups. The rate of in-hospital death did not differ between the groups (5.0% vs. 5.1%; p > 0.999), nor did the post-discharge 1-month (4.0% vs. 3.0%; log-rank p = 0.246) and 1-year (20.6% vs. 19.3%; log-rank p = 0.458) mortality rates. Get With the Guidelines-Heart Failure risk score was calculated for each patient. In multivariate analyses with adjustment for Get With the Guidelines-Heart Failure risk score and other significant clinical covariates and propensity-matched analyses, D2D time was not associated with clinical outcomes. CONCLUSIONS: The D2D time was not associated with clinical outcomes in a large prospective cohort of patients with AHF who were presenting to an ED. (Registry [Prospective Cohort] for Heart Failure in Korea [KorAHF]; NCT01389843).
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
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