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The Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure

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dc.contributor.author강석민-
dc.contributor.author오재원-
dc.date.accessioned2018-08-28T16:58:24Z-
dc.date.available2018-08-28T16:58:24Z-
dc.date.issued2018-
dc.identifier.issn2213-1779-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162126-
dc.description.abstractOBJECTIVES: This study sought to examine the impact of door-to-diuretic (D2D) time on mortality in patients with acute heart failure (AHF) who were presenting to an emergency department (ED). BACKGROUND: Most patients with AHF present with congestion. Early decongestion with diuretic agents could improve their clinical outcomes. METHODS: The Korea Acute Heart Failure registry enrolled 5,625 consecutive patients hospitalized for AHF. For this analysis, the study included patients who received intravenous diuretic agents within 24 h after ED arrival. Early and delayed groups were defined as D2D time </=60 min and D2D time >60 min, respectively. The primary outcomes were in-hospital death and post-discharge death at 1 month and 1 year on the basis of D2D time. RESULTS: A total of 2,761 patients met the inclusion criteria. The median D2D time was 128 min (interquartile range: 63 to 243 min), and 663 (24%) patients belonged to the early group. The baseline characteristics were similar between the groups. The rate of in-hospital death did not differ between the groups (5.0% vs. 5.1%; p > 0.999), nor did the post-discharge 1-month (4.0% vs. 3.0%; log-rank p = 0.246) and 1-year (20.6% vs. 19.3%; log-rank p = 0.458) mortality rates. Get With the Guidelines-Heart Failure risk score was calculated for each patient. In multivariate analyses with adjustment for Get With the Guidelines-Heart Failure risk score and other significant clinical covariates and propensity-matched analyses, D2D time was not associated with clinical outcomes. CONCLUSIONS: The D2D time was not associated with clinical outcomes in a large prospective cohort of patients with AHF who were presenting to an ED. (Registry [Prospective Cohort] for Heart Failure in Korea [KorAHF]; NCT01389843).-
dc.description.statementOfResponsibilityopen-
dc.languageUnited States-
dc.publisher2213-1787-
dc.relation.isPartOfJACC-HEART FAILURE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJin Joo Park-
dc.contributor.googleauthorSun-Hwa Kim-
dc.contributor.googleauthorIl-Young Oh-
dc.contributor.googleauthorDong-Ju Choi-
dc.contributor.googleauthorHyun-Ah Park-
dc.contributor.googleauthorHyun-Jai Cho-
dc.contributor.googleauthorHae-Young Lee-
dc.contributor.googleauthorJae-Yeong Cho-
dc.contributor.googleauthorKye Hun Kim-
dc.contributor.googleauthorJung-Woo Son-
dc.contributor.googleauthorByung-Su Yoo-
dc.contributor.googleauthorJaewon Oh-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSang Hong Baek-
dc.contributor.googleauthorGa Yeon Lee-
dc.contributor.googleauthorJin Oh Choi-
dc.contributor.googleauthorEun-Seok Jeon-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorJae-Joong Kim-
dc.contributor.googleauthorJu-Hee Lee-
dc.contributor.googleauthorMyeong-Chan Cho-
dc.contributor.googleauthorSe Yong Jang-
dc.contributor.googleauthorShung Chull Chae-
dc.contributor.googleauthorByung-Hee Oh-
dc.identifier.doi10.1016/j.jchf.2017.12.017-
dc.contributor.localIdA00037-
dc.contributor.localIdA02395-
dc.relation.journalcodeJ03351-
dc.identifier.eissn2213-1787-
dc.identifier.pmid29598933-
dc.subject.keywordacute heart failure-
dc.subject.keyworddoor-to-diuretic time-
dc.subject.keywordoutcomes-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameOh, Jae Won-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorOh, Jae Won-
dc.citation.volume6-
dc.citation.number4-
dc.citation.startPage286-
dc.citation.endPage294-
dc.identifier.bibliographicCitationJACC-HEART FAILURE, Vol.6(4) : 286-294, 2018-
dc.identifier.rimsid59715-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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