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Magnetic Resonance Imaging for Colorectal Cancer Metastasis to the Liver: Comparative Effectiveness Research for the Choice of Contrast Agents

Authors
 Nieun Seo  ;  Mi-Suk Park  ;  Kyunghwa Han  ;  Kyung Ho Lee  ;  Seong Ho Park  ;  Gi Hong Choi  ;  Jin-Young Choi  ;  Yong Eun Chung  ;  Myeong-Jin Kim 
Citation
 Cancer Research and Treatment, Vol.50(1) : 60-70, 2018 
Journal Title
 Cancer Research and Treatment 
ISSN
 1598-2998 
Issue Date
2018
Keywords
Colorectal neoplasms ; Liver ; Magnetic resonance imaging ; Neoplasm metastasis ; Recurrence
Abstract
PURPOSE: This study was conducted to compare the diagnostic performance and early recurrence rate between gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) and magnetic resonance imaging (MRI) with extracellular contrast agent (ECA-MRI) for evaluating hepatic lesions in colorectal cancer. MATERIALS AND METHODS: Between 2005 and 2010, 418 colorectal cancer patients with both preoperative computed tomography (CT) and liver MRI were retrospectively reviewed. Image analysis was based on initial radiologic reports, and diagnostic performance was assessed based on the area under the receiver operating characteristic curve (AUROC). The early intrahepatic recurrence rate within 6 months was then evaluated. RESULTS: Overall, 291 and 127 patients underwent Gd-EOB-MRI and ECA-MRI, respectively. The AUROCs were not significantly different between Gd-EOB-MRI (0.990; 95% CI, 0.980 to 0.999) and ECA-MRI (0.985; 95% CI, 0.968 to 1.000; p=0.836). When compared with CT alone, ECA-MRI detected additional 21 lesions in 14 patients (14/127, 11.0%), whereas Gd-EOB-MRI detected 56 lesions in 33 patients (33/291, 11.3%) without a significant difference between two MRI groups (p=0.331). The early recurrence rate in the ECA-MRI (28.6%) was significantly higher than that in the Gd-EOB-MRI (11.6%) for patients who underwent hepatic resection (p=0.031). CONCLUSION: Gd-EOB-MRI is potentially better than ECA-MRI for decreasing the early intrahepatic recurrence rate, although the two MRI modalities showed comparable diagnostic performance in colorectal cancer patients.
Files in This Item:
T201800471.pdf Download
DOI
10.4143/crt.2016.533
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
박미숙(Park, Mi-Suk) ORCID logo https://orcid.org/0000-0001-5817-2444
서니은(Seo, Nieun) ORCID logo https://orcid.org/0000-0001-8745-6454
정용은(Chung, Yong Eun) ORCID logo https://orcid.org/0000-0003-0811-9578
최기홍(Choi, Gi Hong) ORCID logo https://orcid.org/0000-0002-1593-3773
최진영(Choi, Jin Young) ORCID logo https://orcid.org/0000-0002-9025-6274
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161997
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