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The association between low level of high-density lipoprotein cholesterol and mood disorder using time-dependent analysis

 Seung Ju Kim  ;  Kyu-Tae Han  ;  Suk-Yong Jang  ;  Eun-Cheol Park 
 Journal of Affective Disorders, Vol.225(1) : 317-325, 2018 
Journal Title
 Journal of Affective Disorders 
Issue Date
Adult ; Aged ; HDL/*blood Cholesterol ; LDL/blood Cholesterol ; Female ; Humans ; HDL/blood Lipoproteins ; Male ; Middle Aged ; Mood Disorders/*blood ; Proportional Hazards Models ; Prospective Studies ; Republic of Korea ; Risk Factors
High-density lipoprotein cholesterol ; Lipid ; Mental health ; Mood disorder
BACKGROUND: Although many studies have identified factors associated with mood disorder, the association between high-density lipoprotein cholesterol (HDL-C) and mood disorder is still controversial. The aim of our study was to evaluate the association between low HDL-C and onset of mood disorder in Korea based on different cut-off levels. METHODS: We used National Health Examinations Service cohort data from 2009 to 2013. We used time-dependent Cox regression analysis to evaluate the association between low level of HDL-C and onset of mood disorder. Hazard ratios (HRs) for onset of mood disorder were estimated for 1- to 2-year time intervals, starting at the first health examination and accounting for the duration until the next health examination. RESULTS: A total of 400,803 participants (male: 220,573; female: 180,230) were included in our study. A total of 4576 (2.07%) males and 7598 (4.22%) females developed mood disorder. Based on dyslipidemia (< 40mg/dL), low level of HDL-C was associated with the risk of mood disorder in both male and female, however, only females showed statistically significant (HR: 1.097, 95% CI: 1.012-1.189). Based on quartile-based approach, females with low levels of HDL-C (< 47mg/dL) and males with high levels of HDL-C (>/= 59mg/dL) were associated with subsequent risk of mood disorder. CONCLUSIONS: Our findings suggest that level of HDL-C is associated with potential risk factors in mood disorder. However, a flexible threshold value in HDL-C level would be needed to evaluate the subsequent risk of mood disorder. Thus, further studies are needed to help improve the mental health in susceptible individuals.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
박은철(Park, Eun-Cheol) ORCID logo https://orcid.org/0000-0002-2306-5398
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