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The association between low level of high-density lipoprotein cholesterol and mood disorder using time-dependent analysis

DC FieldValueLanguage
dc.contributor.author박은철-
dc.date.accessioned2018-08-28T16:50:23Z-
dc.date.available2018-08-28T16:50:23Z-
dc.date.issued2018-
dc.identifier.issn0165-0327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161993-
dc.description.abstractBACKGROUND: Although many studies have identified factors associated with mood disorder, the association between high-density lipoprotein cholesterol (HDL-C) and mood disorder is still controversial. The aim of our study was to evaluate the association between low HDL-C and onset of mood disorder in Korea based on different cut-off levels. METHODS: We used National Health Examinations Service cohort data from 2009 to 2013. We used time-dependent Cox regression analysis to evaluate the association between low level of HDL-C and onset of mood disorder. Hazard ratios (HRs) for onset of mood disorder were estimated for 1- to 2-year time intervals, starting at the first health examination and accounting for the duration until the next health examination. RESULTS: A total of 400,803 participants (male: 220,573; female: 180,230) were included in our study. A total of 4576 (2.07%) males and 7598 (4.22%) females developed mood disorder. Based on dyslipidemia (< 40mg/dL), low level of HDL-C was associated with the risk of mood disorder in both male and female, however, only females showed statistically significant (HR: 1.097, 95% CI: 1.012-1.189). Based on quartile-based approach, females with low levels of HDL-C (< 47mg/dL) and males with high levels of HDL-C (>/= 59mg/dL) were associated with subsequent risk of mood disorder. CONCLUSIONS: Our findings suggest that level of HDL-C is associated with potential risk factors in mood disorder. However, a flexible threshold value in HDL-C level would be needed to evaluate the subsequent risk of mood disorder. Thus, further studies are needed to help improve the mental health in susceptible individuals.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier/North-Holland Biomedical Press-
dc.relation.isPartOfJournal of Affective Disorders-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHHDL/*blood Cholesterol-
dc.subject.MESHLDL/blood Cholesterol-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHDL/blood Lipoproteins-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMood Disorders/*blood-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.titleThe association between low level of high-density lipoprotein cholesterol and mood disorder using time-dependent analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorSeung Ju Kim-
dc.contributor.googleauthorKyu-Tae Han-
dc.contributor.googleauthorSuk-Yong Jang-
dc.contributor.googleauthorEun-Cheol Park-
dc.identifier.doi10.1016/j.jad.2017.08.016-
dc.contributor.localIdA01618-
dc.relation.journalcodeJ01225-
dc.identifier.eissn1573-2517-
dc.identifier.pmid28843914-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0165032717302744-
dc.subject.keywordHigh-density lipoprotein cholesterol-
dc.subject.keywordLipid-
dc.subject.keywordMental health-
dc.subject.keywordMood disorder-
dc.contributor.alternativeNamePark, Eun Chul-
dc.contributor.affiliatedAuthorPark, Eun Chul-
dc.citation.volume225-
dc.citation.number1-
dc.citation.startPage317-
dc.citation.endPage325-
dc.identifier.bibliographicCitationJournal of Affective Disorders, Vol.225(1) : 317-325, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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