Cited 2 times in
The association between low level of high-density lipoprotein cholesterol and mood disorder using time-dependent analysis
DC Field | Value | Language |
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dc.contributor.author | 박은철 | - |
dc.date.accessioned | 2018-08-28T16:50:23Z | - |
dc.date.available | 2018-08-28T16:50:23Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161993 | - |
dc.description.abstract | BACKGROUND: Although many studies have identified factors associated with mood disorder, the association between high-density lipoprotein cholesterol (HDL-C) and mood disorder is still controversial. The aim of our study was to evaluate the association between low HDL-C and onset of mood disorder in Korea based on different cut-off levels. METHODS: We used National Health Examinations Service cohort data from 2009 to 2013. We used time-dependent Cox regression analysis to evaluate the association between low level of HDL-C and onset of mood disorder. Hazard ratios (HRs) for onset of mood disorder were estimated for 1- to 2-year time intervals, starting at the first health examination and accounting for the duration until the next health examination. RESULTS: A total of 400,803 participants (male: 220,573; female: 180,230) were included in our study. A total of 4576 (2.07%) males and 7598 (4.22%) females developed mood disorder. Based on dyslipidemia (< 40mg/dL), low level of HDL-C was associated with the risk of mood disorder in both male and female, however, only females showed statistically significant (HR: 1.097, 95% CI: 1.012-1.189). Based on quartile-based approach, females with low levels of HDL-C (< 47mg/dL) and males with high levels of HDL-C (>/= 59mg/dL) were associated with subsequent risk of mood disorder. CONCLUSIONS: Our findings suggest that level of HDL-C is associated with potential risk factors in mood disorder. However, a flexible threshold value in HDL-C level would be needed to evaluate the subsequent risk of mood disorder. Thus, further studies are needed to help improve the mental health in susceptible individuals. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier/North-Holland Biomedical Press | - |
dc.relation.isPartOf | JOURNAL OF AFFECTIVE DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | HDL/*blood Cholesterol | - |
dc.subject.MESH | LDL/blood Cholesterol | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | HDL/blood Lipoproteins | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mood Disorders/*blood | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Factors | - |
dc.title | The association between low level of high-density lipoprotein cholesterol and mood disorder using time-dependent analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | Seung Ju Kim | - |
dc.contributor.googleauthor | Kyu-Tae Han | - |
dc.contributor.googleauthor | Suk-Yong Jang | - |
dc.contributor.googleauthor | Eun-Cheol Park | - |
dc.identifier.doi | 10.1016/j.jad.2017.08.016 | - |
dc.contributor.localId | A01618 | - |
dc.relation.journalcode | J01225 | - |
dc.identifier.eissn | 1573-2517 | - |
dc.identifier.pmid | 28843914 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0165032717302744 | - |
dc.subject.keyword | High-density lipoprotein cholesterol | - |
dc.subject.keyword | Lipid | - |
dc.subject.keyword | Mental health | - |
dc.subject.keyword | Mood disorder | - |
dc.contributor.alternativeName | Park, Eun Chul | - |
dc.contributor.affiliatedAuthor | Park, Eun Chul | - |
dc.citation.volume | 225 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 317 | - |
dc.citation.endPage | 325 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AFFECTIVE DISORDERS, Vol.225(1) : 317-325, 2018 | - |
dc.identifier.rimsid | 59584 | - |
dc.type.rims | ART | - |
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