74 98

Cited 2 times in

Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway

Authors
 Hyeyon Kim  ;  Haein Kim  ;  Jae Young Kwon  ;  Jeong Taeg Seo  ;  Dong Min Shin  ;  Seok Jun Moon 
Citation
 PLoS Genetics, Vol.14(2) : e1007229, 2018 
Journal Title
 PLoS Genetics 
ISSN
 1553-7390 
Issue Date
2018
MeSH
Animals ; Genetically Modified Animals ; Aristolochic Acids/metabolism ; Drosophila Proteins/genetics/*physiology ; *Drosophila melanogaster/genetics/metabolism ; Fatty Acids/*metabolism ; Glycerol/metabolism ; Lipid Metabolism/genetics ; Maleimides/metabolism ; Cell Surface/genetics/*physiology Receptors ; Signal Transduction/genetics ; Taste/*genetics ; Type C Phospholipases/*metabolism
Abstract
Animals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich nutrients that contribute to various cellular functions. Recent evidence suggests FAs are detected through the gustatory system to promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required for FA detection but other signaling molecules are unknown. Here, we show Gr64e is required for the behavioral and electrophysiological responses to FAs. GR64e and TRPA1 are interchangeable when they act downstream of PLC: TRPA1 can substitute for GR64e in FA but not glycerol sensing, and GR64e can substitute for TRPA1 in aristolochic acid but not N-methylmaleimide sensing. In contrast to its role in FA sensing, GR64e functions as a ligand-gated ion channel for glycerol detection. Our results identify a novel FA transduction molecule and reveal that Drosophila Grs can act via distinct molecular mechanisms depending on context.
Files in This Item:
T201800351.pdf Download
DOI
10.1371/journal.pgen.1007229
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
Shin, Dong Min(신동민) ORCID logo https://orcid.org/0000-0001-6042-0435
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161950
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse