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Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway

DC Field Value Language
dc.contributor.author문석준-
dc.contributor.author서정택-
dc.contributor.author신동민-
dc.date.accessioned2018-08-28T16:48:02Z-
dc.date.available2018-08-28T16:48:02Z-
dc.date.issued2018-
dc.identifier.issn1553-7390-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161950-
dc.description.abstractAnimals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich nutrients that contribute to various cellular functions. Recent evidence suggests FAs are detected through the gustatory system to promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required for FA detection but other signaling molecules are unknown. Here, we show Gr64e is required for the behavioral and electrophysiological responses to FAs. GR64e and TRPA1 are interchangeable when they act downstream of PLC: TRPA1 can substitute for GR64e in FA but not glycerol sensing, and GR64e can substitute for TRPA1 in aristolochic acid but not N-methylmaleimide sensing. In contrast to its role in FA sensing, GR64e functions as a ligand-gated ion channel for glycerol detection. Our results identify a novel FA transduction molecule and reveal that Drosophila Grs can act via distinct molecular mechanisms depending on context.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS GENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHGenetically Modified Animals-
dc.subject.MESHAristolochic Acids/metabolism-
dc.subject.MESHDrosophila Proteins/genetics/*physiology-
dc.subject.MESH*Drosophila melanogaster/genetics/metabolism-
dc.subject.MESHFatty Acids/*metabolism-
dc.subject.MESHGlycerol/metabolism-
dc.subject.MESHLipid Metabolism/genetics-
dc.subject.MESHMaleimides/metabolism-
dc.subject.MESHCell Surface/genetics/*physiology Receptors-
dc.subject.MESHSignal Transduction/genetics-
dc.subject.MESHTaste/*genetics-
dc.subject.MESHType C Phospholipases/*metabolism-
dc.titleDrosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorHyeyon Kim-
dc.contributor.googleauthorHaein Kim-
dc.contributor.googleauthorJae Young Kwon-
dc.contributor.googleauthorJeong Taeg Seo-
dc.contributor.googleauthorDong Min Shin-
dc.contributor.googleauthorSeok Jun Moon-
dc.identifier.doi10.1371/journal.pgen.1007229-
dc.contributor.localIdA01358-
dc.contributor.localIdA01905-
dc.contributor.localIdA02091-
dc.relation.journalcodeJ02538-
dc.identifier.eissn1553-7404-
dc.identifier.pmid29420533-
dc.contributor.alternativeNameMoon, Seok Jun-
dc.contributor.alternativeNameSeo, Jeong Taeg-
dc.contributor.alternativeNameShin, Dong Min-
dc.contributor.affiliatedAuthorMoon, Seok Jun-
dc.contributor.affiliatedAuthorSeo, Jeong Taeg-
dc.contributor.affiliatedAuthorShin, Dong Min-
dc.citation.volume14-
dc.citation.number2-
dc.citation.startPagee1007229-
dc.identifier.bibliographicCitationPLOS GENETICS, Vol.14(2) : e1007229, 2018-
dc.identifier.rimsid59541-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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