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Efficacy and safety of vinorelbine plus cisplatin chemotherapy for patients with recurrent and/or metastatic salivary gland cancer of the head and neck

Authors
 Min Hee Hong  ;  Chang Gon Kim  ;  Yoon Woo Koh  ;  Eun Chang Choi  ;  Jinna Kim  ;  Sun Och Yoon  ;  Hye Ryun Kim  ;  Byoung Chul Cho 
Citation
 Head & Neck, Vol.40(1) : 55-62, 2018 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2018
Keywords
cisplatin ; efficacy ; safety ; salivary gland cancer ; vinorelbine
Abstract
BACKGROUND: The purpose of this study was to investigate the efficacy and safety of vinorelbine plus cisplatin chemotherapy in patients with recurrent and/or metastatic salivary gland cancer of the head and neck. METHODS: In this single-arm phase II study, patients with recurrent and/or metastatic salivary gland cancer were treated with i.v. vinorelbine (25 mg/m(2) ) on days 1 and 8 plus cisplatin (80 mg/m(2) ) on day 1 every 3 weeks for 4 or 6 cycles. The primary endpoint was the objective response rate. Progression-free survival (PFS), overall survival (OS), and adverse events were also assessed. RESULTS: Between September 2008 and November 2014, 40 patients with recurrent and/or metastatic salivary gland cancer received vinorelbine plus cisplatin chemotherapy. The objective response rate was 35.0%, including 1 complete response. Median PFS and OS rates were 6.3 months and 16.9 months, respectively. No treatment-related deaths occurred. CONCLUSION: Administering vinorelbine plus cisplatin chemotherapy to patients with recurrent and/or metastatic salivary gland cancers is safe and effective.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161901
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.24933
DOI
10.1002/hed.24933
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
고윤우(Kho, Yoon Woo)
김진아(Kim, Jinna) ORCID logo https://orcid.org/0000-0002-9978-4356
김혜련(Kim, Hye Ryun)
윤선옥(Yoon, Sun Och) ORCID logo https://orcid.org/0000-0002-5115-1402
조병철(Cho, Byoung Chul)
최은창(Choi, Eun Chang)
홍민희(Hong, Min Hee) ORCID logo https://orcid.org/0000-0003-3490-2195
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