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Ruthenium-106 Brachytherapy with or without Additional Local Therapy Shows Favorable Outcome for Variable-Sized Choroidal Melanomas in Korean Patients

 Yeona Cho  ;  Jee Suk Chang  ;  Jin Sook Yoon  ;  Sung Chul Lee  ;  Yong Bae Kim  ;  Joo Ho Kim  ;  Ki Chang Keum 
 Cancer Research and Treatment, Vol.50(1) : 138-147, 2018 
Journal Title
 Cancer Research and Treatment 
Issue Date
Brachytherapy ; Ruthenium radioisotopes ; Uveal melanoma
PURPOSE: The purpose of this study was to report clinical outcomes of ruthenium-106 ((106)Ru) brachytherapy with or without additional local therapy for choroidal melanomas in Korean patients. MATERIALS AND METHODS: A total of 88 patients diagnosed with choroidal melanomas were treated with (106)Ru brachytherapy between 2006 and 2012. Patients were divided into two groups according to their tumor height: a large group (>/= 6 mm, n=50) and a small group (< 6 mm, n=38). Most patients in the large group received combined therapy with local excision and/or transpupillary thermotherapy. In general, 85-95 Gy was administered to the apex of the tumor, while 100 Gy was administered to the point 2-6 mm from the outer surface of the sclera for patients undergoing combined therapy. RESULTS: The median follow-up duration was 30 months. The 3-year local control rate was significantly higher in the small group than in the large group (94% vs. 70%, p=0.047). The free from distant metastasis (FFDM) rate and the overall survival (OS) rate were also higher in patients in the small group (3-year FFDM, 97% vs. 76%; p=0.031 and 3-year OS, 97% vs. 72%; p=0.036). A total of 13 patients underwent enucleation. The eye-preservation rate was also higher in the small group (3-year eye-preservation rate, 94% vs. 70%; p=0.050), and tumor height was a significant prognostic factor for eye-preservation. CONCLUSION: (106)Ru brachytherapy showed favorable outcomes in small choroidal melanomas in Korean patients. Although additional local treatment could improve eye-preservation rate for large tumors, other strategies should be considered for disease control.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
금기창(Keum, Ki Chang) ORCID logo https://orcid.org/0000-0003-4123-7998
김용배(Kim, Yong Bae) ORCID logo https://orcid.org/0000-0001-7573-6862
김주호(Kim, Joo Ho)
윤진숙(Yoon, Jin Sook) ORCID logo https://orcid.org/0000-0002-8751-9467
이성철(Lee, Sung Chul) ORCID logo https://orcid.org/0000-0001-9438-2385
장지석(Chang, Jee Suk Paul) ORCID logo https://orcid.org/0000-0001-7685-3382
조연아(Cho, Yeona) ORCID logo https://orcid.org/0000-0002-1202-0880
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