Cited 7 times in
Ruthenium-106 Brachytherapy with or without Additional Local Therapy Shows Favorable Outcome for Variable-Sized Choroidal Melanomas in Korean Patients
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 김용배 | - |
dc.contributor.author | 김주호 | - |
dc.contributor.author | 윤진숙 | - |
dc.contributor.author | 이성철 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 조연아 | - |
dc.date.accessioned | 2018-08-28T16:42:21Z | - |
dc.date.available | 2018-08-28T16:42:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161856 | - |
dc.description.abstract | PURPOSE: The purpose of this study was to report clinical outcomes of ruthenium-106 ((106)Ru) brachytherapy with or without additional local therapy for choroidal melanomas in Korean patients. MATERIALS AND METHODS: A total of 88 patients diagnosed with choroidal melanomas were treated with (106)Ru brachytherapy between 2006 and 2012. Patients were divided into two groups according to their tumor height: a large group (>/= 6 mm, n=50) and a small group (< 6 mm, n=38). Most patients in the large group received combined therapy with local excision and/or transpupillary thermotherapy. In general, 85-95 Gy was administered to the apex of the tumor, while 100 Gy was administered to the point 2-6 mm from the outer surface of the sclera for patients undergoing combined therapy. RESULTS: The median follow-up duration was 30 months. The 3-year local control rate was significantly higher in the small group than in the large group (94% vs. 70%, p=0.047). The free from distant metastasis (FFDM) rate and the overall survival (OS) rate were also higher in patients in the small group (3-year FFDM, 97% vs. 76%; p=0.031 and 3-year OS, 97% vs. 72%; p=0.036). A total of 13 patients underwent enucleation. The eye-preservation rate was also higher in the small group (3-year eye-preservation rate, 94% vs. 70%; p=0.050), and tumor height was a significant prognostic factor for eye-preservation. CONCLUSION: (106)Ru brachytherapy showed favorable outcomes in small choroidal melanomas in Korean patients. Although additional local treatment could improve eye-preservation rate for large tumors, other strategies should be considered for disease control. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Ruthenium-106 Brachytherapy with or without Additional Local Therapy Shows Favorable Outcome for Variable-Sized Choroidal Melanomas in Korean Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Yeona Cho | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.contributor.googleauthor | Sung Chul Lee | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Joo Ho Kim | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.identifier.doi | 10.4143/crt.2016.391 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A05464 | - |
dc.contributor.localId | A02611 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A04658 | - |
dc.contributor.localId | A04680 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 28343376 | - |
dc.subject.keyword | Brachytherapy | - |
dc.subject.keyword | Ruthenium radioisotopes | - |
dc.subject.keyword | Uveal melanoma | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Kim, Joo Ho | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.alternativeName | Lee, Sung Chul | - |
dc.contributor.alternativeName | Chang, Jee Suk Paul | - |
dc.contributor.alternativeName | Cho, Yeona | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Kim, Joo Ho | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Sook | - |
dc.contributor.affiliatedAuthor | Lee, Sung Chul | - |
dc.contributor.affiliatedAuthor | Chang, Jee Suk Paul | - |
dc.contributor.affiliatedAuthor | Cho, Yeona | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 138 | - |
dc.citation.endPage | 147 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.50(1) : 138-147, 2018 | - |
dc.identifier.rimsid | 59448 | - |
dc.type.rims | ART | - |
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