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Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes

Authors
 Min Hyuk Choi  ;  Yu Jin Park  ;  Myungsook Kim  ;  Young Hee Seo  ;  Young Ah Kim  ;  Jun Yong Choi  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Kyungwon Lee 
Citation
 Annals of Laboratory Medicine, Vol.38(2) : 102-109, 2018 
Journal Title
 Annals of Laboratory Medicine 
ISSN
 2234-3806 
Issue Date
2018
MeSH
Aged ; Anti-Infective Agents/pharmacology/therapeutic use ; Cross Infection/*diagnosis/drug therapy/epidemiology/mortality ; Female ; Humans ; Incidence ; Listeria monocytogenes/drug effects/genetics/isolation & purification ; Listeriosis/*diagnosis/drug therapy/epidemiology/mortality ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Multilocus Sequence Typing ; Multivariate Analysis ; Odds Ratio ; Republic of Korea/epidemiology ; Retrospective Studies ; Survival Analysis
Keywords
Empirical treatment ; Incidence ; Listeria monocytogenes ; Listeriosis ; Outcome
Abstract
BACKGROUND: Listeriosis caused by Listeria monocytogenes has a high case-fatality rate (CFR) of approximately 20% to 30%. An increasing incidence of listeriosis has been reported in many countries recently. We investigated the annual incidence, clinical characteristics, and outcomes of listeriosis at three different hospitals in Korea and evaluated the effects of appropriate empiric antimicrobial treatments on patient outcomes. METHODS: We retrospectively collected the data of all culture-positive cases of human listeriosis from three hospitals of different sizes in Korea during 2006-2016 and calculated the annual number of cases and incidence per 100,000 admissions. RESULTS: A total of 58 patients with L. monocytogenes were included in this study. The incidence of listeriosis was significantly higher in 2013-2016 than in 2006-2012 (RR 3.1; 95% CI 1.79-5.36; P<0.001), mainly because of an increase in patients over 60 years of age (RR 3.69; 95% CI 1.70-8.02; P<0.001). Multivariate analysis showed that healthcare-associated infection (adjusted OR, 12.15; 95% CI, 2.56-86.01; P=0.004) and empirical treatment with first-line antimicrobial agents (adjusted OR, 0.08; 95% CI, 0.00-0.63; P=0.044) were associated with CFR. CONCLUSIONS: Healthcare-associated infections caused by L. monocytogenes are associated with high CFR. Adequate initial empirical treatments could reduce CFR, suggesting that careful consideration of an empirical antimicrobial regimen is warranted for elderly or immunocompromised patients admitted to the hospital.
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DOI
10.3343/alm.2018.38.2.102
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
정석훈(Jeong, Seok Hoon) ORCID logo https://orcid.org/0000-0001-9290-897X
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161838
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