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Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes

DC FieldValueLanguage
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.contributor.author최준용-
dc.date.accessioned2018-08-28T16:41:08Z-
dc.date.available2018-08-28T16:41:08Z-
dc.date.issued2018-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161838-
dc.description.abstractBACKGROUND: Listeriosis caused by Listeria monocytogenes has a high case-fatality rate (CFR) of approximately 20% to 30%. An increasing incidence of listeriosis has been reported in many countries recently. We investigated the annual incidence, clinical characteristics, and outcomes of listeriosis at three different hospitals in Korea and evaluated the effects of appropriate empiric antimicrobial treatments on patient outcomes. METHODS: We retrospectively collected the data of all culture-positive cases of human listeriosis from three hospitals of different sizes in Korea during 2006-2016 and calculated the annual number of cases and incidence per 100,000 admissions. RESULTS: A total of 58 patients with L. monocytogenes were included in this study. The incidence of listeriosis was significantly higher in 2013-2016 than in 2006-2012 (RR 3.1; 95% CI 1.79-5.36; P<0.001), mainly because of an increase in patients over 60 years of age (RR 3.69; 95% CI 1.70-8.02; P<0.001). Multivariate analysis showed that healthcare-associated infection (adjusted OR, 12.15; 95% CI, 2.56-86.01; P=0.004) and empirical treatment with first-line antimicrobial agents (adjusted OR, 0.08; 95% CI, 0.00-0.63; P=0.044) were associated with CFR. CONCLUSIONS: Healthcare-associated infections caused by L. monocytogenes are associated with high CFR. Adequate initial empirical treatments could reduce CFR, suggesting that careful consideration of an empirical antimicrobial regimen is warranted for elderly or immunocompromised patients admitted to the hospital.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfAnnals of Laboratory Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnti-Infective Agents/pharmacology/therapeutic use-
dc.subject.MESHCross Infection/*diagnosis/drug therapy/epidemiology/mortality-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHListeria monocytogenes/drug effects/genetics/isolation & purification-
dc.subject.MESHListeriosis/*diagnosis/drug therapy/epidemiology/mortality-
dc.subject.MESHMale-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultilocus Sequence Typing-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.titleIncreasing Incidence of Listeriosis and Infection-associated Clinical Outcomes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorMin Hyuk Choi-
dc.contributor.googleauthorYu Jin Park-
dc.contributor.googleauthorMyungsook Kim-
dc.contributor.googleauthorYoung Hee Seo-
dc.contributor.googleauthorYoung Ah Kim-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorKyungwon Lee-
dc.identifier.doi10.3343/alm.2018.38.2.102-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.identifier.pmid29214753-
dc.subject.keywordEmpirical treatment-
dc.subject.keywordIncidence-
dc.subject.keywordListeria monocytogenes-
dc.subject.keywordListeriosis-
dc.subject.keywordOutcome-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.citation.volume38-
dc.citation.number2-
dc.citation.startPage102-
dc.citation.endPage109-
dc.identifier.bibliographicCitationAnnals of Laboratory Medicine, Vol.38(2) : 102-109, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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