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Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults

 Kim Yoon Ji  ;  Hwang Seun Deuk  ;  Oh Tae Jung  ;  Kim Kyoung Min  ;  Jang Hak Chul  ;  Kimm Heejin  ;  Kim Hyeon Chang  ;  Jee Sun Ha  ;  Lim Soo 
 Metabolic Syndrome and Related Disorders, Vol.15(8) : 416-422, 2017 
Journal Title
 Metabolic Syndrome and Related Disorders 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Albuminuria/diagnosis ; Albuminuria/epidemiology ; Albuminuria/etiology ; Comorbidity ; Female ; Glomerular Filtration Rate ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Nutrition Surveys ; Obesity/complications ; Obesity/epidemiology ; Obesity/physiopathology ; Prevalence ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/physiopathology ; Republic of Korea/epidemiology ; Risk Factors ; Young Adult
albuminuria ; chronic kidney disease ; glomerular filtration rate ; obesity
BACKGROUND: Chronic kidney disease (CKD) has often been defined based on glomerular filtration rate (GFR) alone. The Kidney Disease: Improving Global Outcomes guideline highlights albuminuria in the CKD definition. Thus, we investigated the association between obesity and CKD, as defined by both GFR and albuminuria, in Korean adults. METHODS: We used Korea National Health and Nutrition Examination Survey 2011-2014 data (N = 19,331, ≥19 years old) representing the national Korean population. CKD was classified by (1) estimated GFR (eGFR) < 60 mL/min/1.73 m2 (CKDGFR); (2) albumin-to-creatinine ratio (ACR) ≥30 mg/gram (CKDACR); and (3) eGFR < 60 mL/min/1.73 m2 or ACR ≥30 mg/gram (CKDRisk). Associations between obesity and each CKD category were evaluated using multivariate logistic regression analysis. RESULTS: The prevalence rates of CKDGFR, CKDACR, and CKDRisk were 2.2%, 6.7%, and 8.1%, respectively. Compared with the normal body mass index (BMI; 18.5-22.9 kg/m2) group, men with BMI ≥ 25 kg/m2 had 1.88 times greater risk of CKDGFR in the adjusted model [95% confidence interval (CI), 1.26-2.80; P = 0.002]; BMI was not significantly associated with CKDGFR in women. In contrast, both men and women with BMI ≥ 25 kg/m2 had 1.58 and 1.40 times higher risk of CKDACR (95% CI, 1.21-2.07 and 1.08-1.81, respectively, both P < 0.01). Obese men and women had 1.65 and 1.38 times higher risk of CKDRisk (95% CI, 1.29-2.12 and 1.09-1.75, respectively, both P < 0.01). CONCLUSIONS: Obesity was significantly associated with an increased ACR-based CKD risk. Longitudinal studies are needed to investigate the role of overweight and obesity in the development and progression of CKD.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
김현창(Kim, Hyeon Chang) ORCID logo https://orcid.org/0000-0001-7867-1240
김희진(Kimm, Heejin) ORCID logo https://orcid.org/0000-0003-4526-0570
지선하(Jee, Sun Ha) ORCID logo https://orcid.org/0000-0001-9519-3068
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