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Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults

DC FieldValueLanguage
dc.contributor.author김현창-
dc.contributor.author김희진-
dc.contributor.author지선하-
dc.date.accessioned2018-07-20T12:06:01Z-
dc.date.available2018-07-20T12:06:01Z-
dc.date.issued2017-
dc.identifier.issn1540-4196-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161779-
dc.description.abstractBACKGROUND: Chronic kidney disease (CKD) has often been defined based on glomerular filtration rate (GFR) alone. The Kidney Disease: Improving Global Outcomes guideline highlights albuminuria in the CKD definition. Thus, we investigated the association between obesity and CKD, as defined by both GFR and albuminuria, in Korean adults. METHODS: We used Korea National Health and Nutrition Examination Survey 2011-2014 data (N = 19,331, ≥19 years old) representing the national Korean population. CKD was classified by (1) estimated GFR (eGFR) < 60 mL/min/1.73 m2 (CKDGFR); (2) albumin-to-creatinine ratio (ACR) ≥30 mg/gram (CKDACR); and (3) eGFR < 60 mL/min/1.73 m2 or ACR ≥30 mg/gram (CKDRisk). Associations between obesity and each CKD category were evaluated using multivariate logistic regression analysis. RESULTS: The prevalence rates of CKDGFR, CKDACR, and CKDRisk were 2.2%, 6.7%, and 8.1%, respectively. Compared with the normal body mass index (BMI; 18.5-22.9 kg/m2) group, men with BMI ≥ 25 kg/m2 had 1.88 times greater risk of CKDGFR in the adjusted model [95% confidence interval (CI), 1.26-2.80; P = 0.002]; BMI was not significantly associated with CKDGFR in women. In contrast, both men and women with BMI ≥ 25 kg/m2 had 1.58 and 1.40 times higher risk of CKDACR (95% CI, 1.21-2.07 and 1.08-1.81, respectively, both P < 0.01). Obese men and women had 1.65 and 1.38 times higher risk of CKDRisk (95% CI, 1.29-2.12 and 1.09-1.75, respectively, both P < 0.01). CONCLUSIONS: Obesity was significantly associated with an increased ACR-based CKD risk. Longitudinal studies are needed to investigate the role of overweight and obesity in the development and progression of CKD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMary Ann Liebert, Inc.-
dc.relation.isPartOfMETABOLIC SYNDROME AND RELATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlbuminuria/diagnosis-
dc.subject.MESHAlbuminuria/epidemiology-
dc.subject.MESHAlbuminuria/etiology-
dc.subject.MESHComorbidity-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHumans-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHObesity/complications-
dc.subject.MESHObesity/epidemiology-
dc.subject.MESHObesity/physiopathology-
dc.subject.MESHPrevalence-
dc.subject.MESHRenal Insufficiency, Chronic/complications-
dc.subject.MESHRenal Insufficiency, Chronic/diagnosis-
dc.subject.MESHRenal Insufficiency, Chronic/epidemiology-
dc.subject.MESHRenal Insufficiency, Chronic/physiopathology-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHYoung Adult-
dc.titleAssociation Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorKim Yoon Ji-
dc.contributor.googleauthorHwang Seun Deuk-
dc.contributor.googleauthorOh Tae Jung-
dc.contributor.googleauthorKim Kyoung Min-
dc.contributor.googleauthorJang Hak Chul-
dc.contributor.googleauthorKimm Heejin-
dc.contributor.googleauthorKim Hyeon Chang-
dc.contributor.googleauthorJee Sun Ha-
dc.contributor.googleauthorLim Soo-
dc.identifier.doi10.1089/met.2017.0053-
dc.contributor.localIdA01142-
dc.contributor.localIdA01226-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ02222-
dc.identifier.eissn1557-8518-
dc.identifier.pmid28832275-
dc.identifier.urlhttps://www.liebertpub.com/doi/pdf/10.1089/met.2017.0053-
dc.subject.keywordalbuminuria-
dc.subject.keywordchronic kidney disease-
dc.subject.keywordglomerular filtration rate-
dc.subject.keywordobesity-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameKimm, Hee Jin-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorKimm, Hee Jin-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.citation.volume15-
dc.citation.number8-
dc.citation.startPage416-
dc.citation.endPage422-
dc.identifier.bibliographicCitationMETABOLIC SYNDROME AND RELATED DISORDERS, Vol.15(8) : 416-422, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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