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Long-Term Outcome of Amyotrophic Lateral Sclerosis in Korean Subjects

Other Titles
 근위축성 측삭 경화증 환자의 장기 추적 관찰 결과 
 Mi Ri Suh  ;  Won Ah Choi  ;  Young-Chul Choi  ;  Jang Woo Lee  ;  Jung Hwa Hong  ;  Jihyun Park  ;  Seong-Woong Kang 
 Annals of Rehabilitation Medicine, Vol.41(6) : 1055, 2017 
Journal Title
Annals of Rehabilitation Medicine
Issue Date
Amyotrophic lateral sclerosis ; Prognosis ; Survival
Objective: To report the latest long-term outcome of amyotrophic lateral sclerosis (ALS) and to analyze the predictors of prognosis.

Methods: Subjects who were diagnosed with ALS between January 2005 and December 2009 at a single institute were followed up until death or up to December 2014. Data regarding age, sex, date of onset, date of diagnosis, presence of bulbar symptoms on onset, date of initiation of non-invasive ventilation (NIV), and the date of tracheostomy were collected. Survival was assessed using Kaplan-Meier curves and multivariate analyses of the risk of death were performed using the Cox proportional hazards model.

Results: Among 212 suspicious subjects, definite ALS was diagnosed in 182 subjects. The survival rate at 3 and 5 years from onset was 61.5% and 40.1%, respectively, and the survival rate at 3 and 5 years post-diagnosis was 49.5% and 24.2%, respectively. Further, 134 patients (134/182, 73.6%) were initiated on NIV, and among them, 90 patients (90/182, 49.5%) underwent tracheostomy. Male gender and onset age of ≥65 years were independent predictors of adverse survival.

Conclusion: The analysis of long term survival in ALS showed excellent outcomes considering the overall poor prognosis of this disease.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Seong Woong(강성웅) ORCID logo https://orcid.org/0000-0002-7279-3893
Park, Jihyun(박지현) ORCID logo https://orcid.org/0000-0002-2172-1072
Suh, Mi Ri(서미리)
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
Choi, Won Ah(최원아) ORCID logo https://orcid.org/0000-0003-0403-8869
Hong, Jung Hwa(홍정화)
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