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Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence

Authors
 Yu-Mi Lee  ;  Chae-Myeong Ha  ;  Se-A Kim  ;  Themis Thoudam  ;  Young-Ran Yoon  ;  Dae-Jung Kim  ;  Hyeon-Chang Kim  ;  Hyo-Bang Moon  ;  Sungmi Park  ;  In-Kyu Lee  ;  Duk-Hee Lee 
Citation
 Diabetes, Vol.66(10) : 2669-2680, 2017 
Journal Title
 Diabetes 
ISSN
 0012-1797 
Issue Date
2017
MeSH
Adult ; Animals ; Cell Line ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism* ; Environmental Pollutants/blood ; Environmental Pollutants/toxicity* ; Female ; Glucose Tolerance Test ; Humans ; Hydrocarbons, Chlorinated/blood ; Hydrocarbons, Chlorinated/toxicity ; Insulin/secretion* ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism* ; Male ; Middle Aged ; Polychlorinated Biphenyls/blood ; Polychlorinated Biphenyls/toxicity ; Rats
Abstract
Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor for type 2 diabetes. We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of β-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 adults without diabetes. Mathematical model-based insulin secretion indices were estimated by using a 2-h seven-sample oral glucose tolerance test. Insulin secretion by INS-1E β-cells was measured after 48 h of treatment with three OCPs or one PCB mixture. Static second-phase insulin secretion significantly decreased with increasing serum concentrations of OCPs. Adjusted means were 63.2, 39.3, 44.1, 39.3, 39.7, and 22.3 across six categories of a summary measure of OCPs (Ptrend = 0.02). Dynamic first-phase insulin secretion remarkably decreased with increasing concentrations of OCPs among only insulin-sensitive individuals (Ptrend = 0.02); the insulin levels among individuals with high OCPs were ∼30% of those with low OCPs. Compared with OCPs, PCBs showed weaker associations. The decreased insulin secretion by INS-1E β-cells was observed for even 1 pmol/L OCP. The data from human and in vitro cell experiments suggest that chronic exposure to low-dose POPs, especially OCPs, can induce pancreatic β-cell dysfunction.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161512
DOI
10.2337/db17-0188
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
Yonsei Authors
김현창(Kim, Hyeon Chang)
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