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Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence

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dc.contributor.author김현창-
dc.date.accessioned2018-07-20T11:55:58Z-
dc.date.available2018-07-20T11:55:58Z-
dc.date.issued2017-
dc.identifier.issn0012-1797-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161512-
dc.description.abstractLow-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor for type 2 diabetes. We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of β-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 adults without diabetes. Mathematical model-based insulin secretion indices were estimated by using a 2-h seven-sample oral glucose tolerance test. Insulin secretion by INS-1E β-cells was measured after 48 h of treatment with three OCPs or one PCB mixture. Static second-phase insulin secretion significantly decreased with increasing serum concentrations of OCPs. Adjusted means were 63.2, 39.3, 44.1, 39.3, 39.7, and 22.3 across six categories of a summary measure of OCPs (Ptrend = 0.02). Dynamic first-phase insulin secretion remarkably decreased with increasing concentrations of OCPs among only insulin-sensitive individuals (Ptrend = 0.02); the insulin levels among individuals with high OCPs were ∼30% of those with low OCPs. Compared with OCPs, PCBs showed weaker associations. The decreased insulin secretion by INS-1E β-cells was observed for even 1 pmol/L OCP. The data from human and in vitro cell experiments suggest that chronic exposure to low-dose POPs, especially OCPs, can induce pancreatic β-cell dysfunction.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Diabetes Association-
dc.relation.isPartOfDIABETES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line-
dc.subject.MESHDiabetes Mellitus, Type 2/blood-
dc.subject.MESHDiabetes Mellitus, Type 2/metabolism*-
dc.subject.MESHEnvironmental Pollutants/blood-
dc.subject.MESHEnvironmental Pollutants/toxicity*-
dc.subject.MESHFemale-
dc.subject.MESHGlucose Tolerance Test-
dc.subject.MESHHumans-
dc.subject.MESHHydrocarbons, Chlorinated/blood-
dc.subject.MESHHydrocarbons, Chlorinated/toxicity-
dc.subject.MESHInsulin/secretion*-
dc.subject.MESHInsulin-Secreting Cells/drug effects-
dc.subject.MESHInsulin-Secreting Cells/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolychlorinated Biphenyls/blood-
dc.subject.MESHPolychlorinated Biphenyls/toxicity-
dc.subject.MESHRats-
dc.titleLow-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorYu-Mi Lee-
dc.contributor.googleauthorChae-Myeong Ha-
dc.contributor.googleauthorSe-A Kim-
dc.contributor.googleauthorThemis Thoudam-
dc.contributor.googleauthorYoung-Ran Yoon-
dc.contributor.googleauthorDae-Jung Kim-
dc.contributor.googleauthorHyeon-Chang Kim-
dc.contributor.googleauthorHyo-Bang Moon-
dc.contributor.googleauthorSungmi Park-
dc.contributor.googleauthorIn-Kyu Lee-
dc.contributor.googleauthorDuk-Hee Lee-
dc.identifier.doi10.2337/db17-0188-
dc.contributor.localIdA01142-
dc.relation.journalcodeJ00718-
dc.identifier.eissn1939-327X-
dc.identifier.pmid28720696-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.citation.volume66-
dc.citation.number10-
dc.citation.startPage2669-
dc.citation.endPage2680-
dc.identifier.bibliographicCitationDIABETES, Vol.66(10) : 2669-2680, 2017-
dc.identifier.rimsid61418-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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