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Uric Acid Level Has a J-Shaped Association with Arterial Stiffness in Korean Postmenopausal Women

 Hyungbin Lee  ;  Young-Hyo Jung  ;  Yu-Jin Kwon  ;  Byoungjin Park 
 Korean Journal of Family Medicine, Vol.38(6) : 333-337, 2017 
Journal Title
Korean Journal of Family Medicine(가정의학회지)
Issue Date
Cardiovascular Diseases ; Menopause ; Uric Acid ; Vascular Stiffness
Background: Uric acid has been reported to function both as an oxidant or antioxidant depending on the context. A previous study in the Korean population reported a positive linear association between serum uric acid level and arterial stiffness in men, but little is known about how serum uric acid level is related to the risk of increased arterial stiffness in Korean postmenopausal women.

Methods: We performed a cross-sectional study of 293 subjects who participated in a health examination program run by the health promotion center of Gangnam Severance Hospital between October 2007 and July 2010. High brachial-ankle pulse wave velocity was defined as a brachial-ankle pulse wave velocity of more than 1,450 cm/s. The odds ratios (ORs) for high brachial-ankle pulse wave velocity were calculated using multivariate logistic regression analysis across uric acid quartiles after adjusting for other indicators of cardiovascular risk.

Results: The 293 postmenopausal women were divided into quartiles according to uric acid level. The mean brachial-ankle pulse wave velocity values of each quartile were as follows: Q1, 1,474 cm/s; Q2, 1,375 cm/s; Q3, 1,422 cm/s; Q4, 1,528 cm/s. The second quartile was designated as the control group based on mean brachial-ankle pulse wave velocity value. Multivariate adjusted ORs (95% confidence intervals) for brachial-ankle pulse wave velocity across the uric acid quartiles were 2.642 (Q1, 1.095-6.3373), 1.00, 4.305 (Q3, 1.798-10.307), and 4.375 (Q4, 1.923-9.949), after adjusting for confounding variables.

Conclusion: Serum uric acid level has a J-shaped association with arterial stiffness in Korean postmenopausal women.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Hyungbin(이형빈)
Jung, Young Hyo(정영효)
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