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High Calcium-Magnesium Ratio in Hair Is Associated with Coronary Artery Calcification in Middle-Aged and Elderly Individuals

 Byoungjin Park  ;  Mi-Hyun Kim  ;  Choong Keun Cha  ;  Yong-Jae Lee  ;  Kyong-Chol Kim 
 Biological Trace Element Research, Vol.179(1) : 52-58, 2017 
Journal Title
 Biological Trace Element Research 
Issue Date
Calcium–magnesium ratio ; Coronary calcium score ; Hair analysis ; Subclinical coronary artery disease
The interaction between calcium and magnesium as a risk modifier for cardiovascular disease (CVD) has been largely overlooked in previous studies, for the strict regulatory system in blood has been thought to keep such homeostatic interactions under tight control. This study aimed to investigate the association between calcium-magnesium ratio in hair and subclinical coronary artery calcification. Using multiple linear regression analysis, we examined the associations between calcium-magnesium ratio in hair and the coronary calcium score (CCS) in 216 Koreans aged 40 years and above (122 men and 94 women). We found that the calcium-to-magnesium ratio in hair was independently and positively associated with CCS after adjusting for age and sex (regression coefficient 6.051 ± 2.329, P = 0.010). When we assessed the association between the calcium-magnesium ratio and CCS after adjusting for potential cardiovascular risk factors and vascular function modifying drugs, we found that the strength of association with CCS was comparable to before (regression coefficient 5.434 ± 2.523, P = 0.032). Our findings suggest that among middle-aged and elderly Koreans without clinical CVD, the association between coronary artery calcification and hair calcium-magnesium ratio is stronger in those with a higher calcium-magnesium ratio in hair than in those with a lower ratio.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
Yonsei Authors
박병진(Park, Byoung Jin) ORCID logo https://orcid.org/0000-0003-1733-5301
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
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