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Clinical significance of lactate clearance for the development of early allograft dysfunction and short-term prognosis in deceased donor liver transplantation

 Deok Gie Kim  ;  Jee Youn Lee  ;  Yoon Bin Jung  ;  Seung Hwan Song  ;  Jae Geun Lee  ;  Dai Hoon Han  ;  Dong Jin Joo  ;  Man Ki Ju  ;  Gi Hong Choi  ;  Jin Sub Choi  ;  Myoung Soo Kim  ;  Soon Il Kim 
 Clinical Transplantation, Vol.31(12) : e13136, 2017 
Journal Title
 Clinical Transplantation 
Issue Date
early allograft dysfunction ; lactate clearance ; liver transplantation
This retrospective study evaluated lactate clearance (LC), measured at 6, 12, 18, and 24 hours after reperfusion, as a predictor of early allograft dysfunction (EAD) and short-term outcomes in patients receiving deceased donor liver transplantation. Of 181 transplant recipients, 44 (24.3%) developed EAD and had lower LCs than those who did not develop EAD. A receiver operating characteristic analysis showed that LC determined at 6 hours showed the highest area under curve value of 0.828 (95% confidence interval [CI]: 0.755-0.990) for predicting the development of EAD at a cutoff value of 25.8% with 76.7% sensitivity and 77.9% specificity. LC values that fell below the cutoff values were significantly associated with EAD in a multivariate analysis, with values at 6 hours having the highest adjusted odds ratio (11.891, 95% CI: 4.469-31.639). In-hospital and 6 month mortalities were higher in patients with LC values below the cutoffs compared with those above the cutoff values at each time point. Thus, LC calculated shortly after reperfusion of an allograft is significantly discriminative for the development of EAD and is associated with short-term prognosis after deceased donor liver transplantation.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김덕기(Kim, Deok Gie)
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
이재근(Lee, Jae Geun) ORCID logo https://orcid.org/0000-0002-6722-0257
이지연(Lee, Jee Youn)
주동진(Joo, Dong Jin) ORCID logo https://orcid.org/0000-0001-8405-1531
주만기(Joo, Man Ki)
최기홍(Choi, Gi Hong) ORCID logo https://orcid.org/0000-0002-1593-3773
최진섭(Choi, Jin Sub)
한대훈(Han, Dai Hoon) ORCID logo https://orcid.org/0000-0003-2787-7876
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