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Clinical significance of lactate clearance for the development of early allograft dysfunction and short-term prognosis in deceased donor liver transplantation

DC FieldValueLanguage
dc.contributor.author김덕기-
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.contributor.author이재근-
dc.contributor.author이지연-
dc.contributor.author주동진-
dc.contributor.author주만기-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.contributor.author한대훈-
dc.date.accessioned2018-07-20T11:54:34Z-
dc.date.available2018-07-20T11:54:34Z-
dc.date.issued2017-
dc.identifier.issn0902-0063-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161484-
dc.description.abstractThis retrospective study evaluated lactate clearance (LC), measured at 6, 12, 18, and 24 hours after reperfusion, as a predictor of early allograft dysfunction (EAD) and short-term outcomes in patients receiving deceased donor liver transplantation. Of 181 transplant recipients, 44 (24.3%) developed EAD and had lower LCs than those who did not develop EAD. A receiver operating characteristic analysis showed that LC determined at 6 hours showed the highest area under curve value of 0.828 (95% confidence interval [CI]: 0.755-0.990) for predicting the development of EAD at a cutoff value of 25.8% with 76.7% sensitivity and 77.9% specificity. LC values that fell below the cutoff values were significantly associated with EAD in a multivariate analysis, with values at 6 hours having the highest adjusted odds ratio (11.891, 95% CI: 4.469-31.639). In-hospital and 6 month mortalities were higher in patients with LC values below the cutoffs compared with those above the cutoff values at each time point. Thus, LC calculated shortly after reperfusion of an allograft is significantly discriminative for the development of EAD and is associated with short-term prognosis after deceased donor liver transplantation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMunksgaard-
dc.relation.isPartOfClinical Transplantation-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical significance of lactate clearance for the development of early allograft dysfunction and short-term prognosis in deceased donor liver transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorDeok Gie Kim-
dc.contributor.googleauthorJee Youn Lee-
dc.contributor.googleauthorYoon Bin Jung-
dc.contributor.googleauthorSeung Hwan Song-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorDai Hoon Han-
dc.contributor.googleauthorDong Jin Joo-
dc.contributor.googleauthorMan Ki Ju-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorSoon Il Kim-
dc.identifier.doi10.1111/ctr.13136-
dc.contributor.localIdA05303-
dc.contributor.localIdA00424-
dc.contributor.localIdA00649-
dc.contributor.localIdA03068-
dc.contributor.localIdA04787-
dc.contributor.localIdA03948-
dc.contributor.localIdA03949-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA04273-
dc.relation.journalcodeJ00615-
dc.identifier.eissn1399-0012-
dc.identifier.pmid29032588-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.13136-
dc.subject.keywordearly allograft dysfunction-
dc.subject.keywordlactate clearance-
dc.subject.keywordliver transplantation-
dc.contributor.alternativeNameKim, Deok Gie-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameLee, Jae Geun-
dc.contributor.alternativeNameLee, Jee Youn-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.alternativeNameJoo, Man Ki-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameHan, Dai Hoon-
dc.contributor.affiliatedAuthorKim, Deok Gie-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorLee, Jae Geun-
dc.contributor.affiliatedAuthorLee, Jee Youn-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorJoo, Man Ki-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorHan, Dai Hoon-
dc.citation.volume31-
dc.citation.number12-
dc.citation.startPagee13136-
dc.identifier.bibliographicCitationClinical Transplantation, Vol.31(12) : e13136, 2017-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)

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