13 23

Cited 0 times in

Relation Between Blood Pressure and Clinical Outcome in Hypertensive Subjects With Previous Str

Authors
 Chan Joo Lee  ;  Jinseub Hwang  ;  Jaewon Oh  ;  Sang‐Hak Lee  ;  Seok‐Min Kang  ;  Hyeon Chang Kim  ;  Sungha Park 
Citation
 Journal of the American Heart Association, Vol.6(12) : e007102, 2017 
Journal Title
 Journal of the American Heart Association 
Issue Date
2017
Keywords
hypertension ; mortality ; myocardial infarction ; stroke
Abstract
BACKGROUND: This study investigated whether a mean blood pressure (BP) of <130/80 mm Hg is associated with further reduction in cardiovascular outcomes in treated hypertensive subjects with previous stroke. METHODS AND RESULTS: Subjects from the Korea National Health Insurance Service health examinee cohort diagnosed as having stroke and hypertension from January 1st, 2003 and December 31st, 2006 (N=2320) were grouped according to mean systolic (<130, 130-<140, and ≥140 mm Hg) and diastolic (<80, 80-<90, and ≥90 mm Hg) BP recorded during follow-up health examinations. All-cause and cardiovascular mortality over 11 years were compared. Compared with subjects with a systolic BP of ≥140 mm Hg (N=736), subjects with a systolic BP of 130 to <140 mm Hg (N=793) had a significantly lower risk of all-cause death (hazard ratio [HR], 0.61; 95% confidence interval [CI], 0.47-0.79; P<0.001), cardiovascular mortality (HR, 0.39; 95% CI, 0.25-0.61; P<0.001), and fatal ischemic stroke (HR, 0.25; 95% CI, 0.10-0.63; P=0.003). Systolic BP of <130 mm Hg (N=791) was associated with lower risk of nonfatal hemorrhagic stroke. Subjects with a diastolic BP of 80 to <90 mm Hg (N=1100) had significantly lower risk of all-cause death (HR, 0.60, 95% CI, 0.45-0.80; P<0.001) and cardiovascular mortality (HR, 0.45; 95% CI, 0.30-0.70; P<0.001) than those with a diastolic BP of ≥90 mm Hg (N=342). Diastolic BP of <80 mm Hg (N=878) was associated with reduced risk of nonfatal hemorrhagic stroke and further lowering of all-cause mortality and cardiovascular mortality. CONCLUSIONS: BP of <130/80 mm Hg was associated with improved outcomes in hypertensive subjects with previous stroke.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161483
DOI
10.1161/JAHA.117.007102
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
Yonsei Authors
강석민(Kang, Seok Min)
김현창(Kim, Hyeon Chang)
박성하(Park, Sung Ha)
오재원(Oh, Jae Won)
이상학(Lee, Sang Hak)
사서에게 알리기
  feedback
Files in This Item:
T201704924.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse