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Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

Authors
 Lee J.-Y.  ;  Kim J.-H.  ;  Lee D.-C. 
Citation
 Dementia and Geriatric Cognitive Disorders, Vol.44(3~4) : 232-243, 2017 
Journal Title
 Dementia and Geriatric Cognitive Disorders 
ISSN
 1420-8008 
Issue Date
2017
Keywords
Aging ; Cognitive decline ; Mitochondrial DNA copy number ; Telomere length ; Very old adults
Abstract
BACKGROUND: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. METHODS: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. RESULTS: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0.23 (95% confidence interval (CI), 0.10-0.75) and 0.18 (95% CI, 0.03-0.54), respectively. Participants in the high telomere length/high mtDNA copy number group were more likely to have cognitive dysfunction than participants in the low telomere/low mtDNA copy number group with an adjusted odds ratio of 0.19 (95% CI, 0.07-0.58). CONCLUSION: Our results collectively suggest that the combination of telomere length and mtDNA copy number may be useful for monitoring cognitive decline in older adults.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161445
DOI
10.1159/000480427
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
Yonsei Authors
이덕철(Lee, Duk Chul)
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Full Text
https://www.karger.com/Article/Abstract/480427
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