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Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

DC FieldValueLanguage
dc.contributor.author이덕철-
dc.date.accessioned2018-07-20T11:52:57Z-
dc.date.available2018-07-20T11:52:57Z-
dc.date.issued2017-
dc.identifier.issn1420-8008-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161445-
dc.description.abstractBACKGROUND: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. METHODS: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. RESULTS: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0.23 (95% confidence interval (CI), 0.10-0.75) and 0.18 (95% CI, 0.03-0.54), respectively. Participants in the high telomere length/high mtDNA copy number group were more likely to have cognitive dysfunction than participants in the low telomere/low mtDNA copy number group with an adjusted odds ratio of 0.19 (95% CI, 0.07-0.58). CONCLUSION: Our results collectively suggest that the combination of telomere length and mtDNA copy number may be useful for monitoring cognitive decline in older adults.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKarger-
dc.relation.isPartOfDementia and Geriatric Cognitive Disorders-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCombined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Family Medicine-
dc.contributor.googleauthorLee J.-Y.-
dc.contributor.googleauthorKim J.-H.-
dc.contributor.googleauthorLee D.-C.-
dc.identifier.doi10.1159/000480427-
dc.contributor.localIdA02716-
dc.relation.journalcodeJ00696-
dc.identifier.eissn1421-9824-
dc.identifier.pmid28982094-
dc.identifier.urlhttps://www.karger.com/Article/Abstract/480427-
dc.subject.keywordAging-
dc.subject.keywordCognitive decline-
dc.subject.keywordMitochondrial DNA copy number-
dc.subject.keywordTelomere length-
dc.subject.keywordVery old adults-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.citation.volume44-
dc.citation.number3~4-
dc.citation.startPage232-
dc.citation.endPage243-
dc.identifier.bibliographicCitationDementia and Geriatric Cognitive Disorders, Vol.44(3~4) : 232-243, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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