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Vascular and metabolic comorbidities in open-angle glaucoma with low- and high-teen intraocular pressure: a cross-sectional study from South Korea

 Si Hyung Lee  ;  Gyu Ah Kim  ;  Wonseok Lee  ;  Hyoung Won Bae  ;  Gong Je Seong  ;  Chan Yun Kim 
 ACTA OPHTHALMOLOGICA, Vol.95(7) : e564-e574, 2017 
Journal Title
Issue Date
Adult ; Aged ; Comorbidity ; Cross-Sectional Studies ; Female ; Glaucoma, Open-Angle/epidemiology* ; Glaucoma, Open-Angle/physiopathology ; Humans ; Hyperlipidemias/epidemiology* ; Hypertension/epidemiology* ; Intraocular Pressure/physiology* ; Male ; Middle Aged ; Nutrition Surveys* ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors
diabetes ; hyperlipidemia ; hypertension ; metabolic syndrome ; normal-tension glaucoma
PURPOSE: To assess the associations between vascular and metabolic comorbidities and the prevalence of open-angle glaucoma (OAG) with low-teen and high-teen intraocular pressure (IOP) in Korea.

METHODS: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2012 were analysed. Participants diagnosed with OAG with normal IOP were further classified into low-teen IOP (IOP ≤ 15 mmHg) and high-teen IOP (15 mmHg < IOP ≤ 21 mmHg) groups. Using multiple logistic regression analyses, the associations between vascular and metabolic comorbidities and the prevalence of glaucoma were investigated for the low- and high-teen IOP groups.

RESULTS: The prevalences of hypertension, hyperlipidemia, ischaemic heart disease, stroke and metabolic syndrome were significantly higher among subjects with low-teen OAG compared with normal subjects, while only the prevalences of hypertension and stroke were higher among subjects with high-teen OAG compared with normal subjects. In multivariate logistic regression models adjusted for confounding factors, low-teen OAG was significantly associated with hypertension (OR, 1.68; 95% CI, 1.30-2.18), hyperlipidemia (OR, 1.49; 95% CI, 1.07-2.08), ischaemic heart disease (OR, 1.83; 95% CI, 1.07-3.11), stroke (OR, 1.91; 95% CI, 1.12-3.25) and metabolic syndrome (OR, 1.46; 95% CI, 1.12-1.90). High-teen OAG was only associated with stroke (OR, 2.58; 95% CI, 1.20-5.53).

CONCLUSION: Various vascular and metabolic comorbidities were significantly associated with low-teen OAG, but not with high-teen OAG. These data support the hypothesis that vascular factors play a more significant role in the pathogenesis of OAG with low-teen baseline IOP.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gyuah(김규아)
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Si Hyung(이시형)
Lee, Wonseok(이원석)
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