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Vascular and metabolic comorbidities in open-angle glaucoma with low- and high-teen intraocular pressure: a cross-sectional study from South Korea

DC FieldValueLanguage
dc.contributor.author김규아-
dc.contributor.author김찬윤-
dc.contributor.author배형원-
dc.contributor.author성공제-
dc.contributor.author이시형-
dc.contributor.author이원석-
dc.date.accessioned2018-07-20T08:47:39Z-
dc.date.available2018-07-20T08:47:39Z-
dc.date.issued2017-
dc.identifier.issn1755-375X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161397-
dc.description.abstractPURPOSE: To assess the associations between vascular and metabolic comorbidities and the prevalence of open-angle glaucoma (OAG) with low-teen and high-teen intraocular pressure (IOP) in Korea. METHODS: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2012 were analysed. Participants diagnosed with OAG with normal IOP were further classified into low-teen IOP (IOP ≤ 15 mmHg) and high-teen IOP (15 mmHg < IOP ≤ 21 mmHg) groups. Using multiple logistic regression analyses, the associations between vascular and metabolic comorbidities and the prevalence of glaucoma were investigated for the low- and high-teen IOP groups. RESULTS: The prevalences of hypertension, hyperlipidemia, ischaemic heart disease, stroke and metabolic syndrome were significantly higher among subjects with low-teen OAG compared with normal subjects, while only the prevalences of hypertension and stroke were higher among subjects with high-teen OAG compared with normal subjects. In multivariate logistic regression models adjusted for confounding factors, low-teen OAG was significantly associated with hypertension (OR, 1.68; 95% CI, 1.30-2.18), hyperlipidemia (OR, 1.49; 95% CI, 1.07-2.08), ischaemic heart disease (OR, 1.83; 95% CI, 1.07-3.11), stroke (OR, 1.91; 95% CI, 1.12-3.25) and metabolic syndrome (OR, 1.46; 95% CI, 1.12-1.90). High-teen OAG was only associated with stroke (OR, 2.58; 95% CI, 1.20-5.53). CONCLUSION: Various vascular and metabolic comorbidities were significantly associated with low-teen OAG, but not with high-teen OAG. These data support the hypothesis that vascular factors play a more significant role in the pathogenesis of OAG with low-teen baseline IOP.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Munksgaard-
dc.relation.isPartOfACTA OPHTHALMOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHComorbidity-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHGlaucoma, Open-Angle/epidemiology*-
dc.subject.MESHGlaucoma, Open-Angle/physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHHyperlipidemias/epidemiology*-
dc.subject.MESHHypertension/epidemiology*-
dc.subject.MESHIntraocular Pressure/physiology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNutrition Surveys*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.titleVascular and metabolic comorbidities in open-angle glaucoma with low- and high-teen intraocular pressure: a cross-sectional study from South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorSi Hyung Lee-
dc.contributor.googleauthorGyu Ah Kim-
dc.contributor.googleauthorWonseok Lee-
dc.contributor.googleauthorHyoung Won Bae-
dc.contributor.googleauthorGong Je Seong-
dc.contributor.googleauthorChan Yun Kim-
dc.identifier.doi10.1111/aos.13487-
dc.contributor.localIdA00326-
dc.contributor.localIdA01035-
dc.contributor.localIdA01814-
dc.contributor.localIdA01946-
dc.contributor.localIdA04630-
dc.contributor.localIdA05378-
dc.relation.journalcodeJ00025-
dc.identifier.eissn1755-3768-
dc.identifier.pmid28677865-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/aos.13487-
dc.subject.keyworddiabetes-
dc.subject.keywordhyperlipidemia-
dc.subject.keywordhypertension-
dc.subject.keywordmetabolic syndrome-
dc.subject.keywordnormal-tension glaucoma-
dc.contributor.alternativeNameKim, Gyuah-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.alternativeNameBae, Hyoung Won-
dc.contributor.alternativeNameSeong, Gong Je-
dc.contributor.alternativeNameLee, Si Hyung-
dc.contributor.alternativeNameLee, Wonseok-
dc.contributor.affiliatedAuthorKim, Gyuah-
dc.contributor.affiliatedAuthorKim, Chan Yun-
dc.contributor.affiliatedAuthorBae, Hyoung Won-
dc.contributor.affiliatedAuthorSeong, Gong Je-
dc.contributor.affiliatedAuthorLee, Si Hyung-
dc.contributor.affiliatedAuthorLee, Wonseok-
dc.citation.volume95-
dc.citation.number7-
dc.citation.startPagee564-
dc.citation.endPagee574-
dc.identifier.bibliographicCitationACTA OPHTHALMOLOGICA, Vol.95(7) : e564-e574, 2017-
dc.identifier.rimsid61315-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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