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Programmed cell death 1 expression is associated with inferior survival in patients with primary central nervous system lymphoma

Authors
 Hyunsoo Cho  ;  Se Hoon Kim  ;  Soo-Jeong Kim  ;  Jong Hee Chang  ;  Woo-Ick Yang  ;  Chang-Ok Suh  ;  Yu Ri Kim  ;  Ji Eun Jang  ;  June-Won Cheong  ;  Yoo Hong Min  ;  Jin Seok Kim 
Citation
 Oncotarget, Vol.8(50) : 87317-87328, 2017 
Journal Title
 Oncotarget 
Issue Date
2017
Keywords
primary central nervous system lymphoma ; prognosis ; programmed cell death 1 ; programmed cell death-ligand 1 ; programmed cell death-ligand 2
Abstract
Programmed cell death 1 (PD-1) and its ligands PD-L1/PD-L2 have been shown to mediate immune evasion in various cancers, but their prognostic implications in patients with primary central nervous system lymphoma (PCNSL) are poorly understood. Therefore, we analyzed 76 PCNSL patients at initial diagnosis who were treated homogenously with high-dose methotrexate-based chemotherapy, and evaluated the prognostic roles of high immunohistochemical PD-1, PD-L1, and PD-L2 expression. The cut-off values for high PD-1 (≥ 70 cells/high power field [HPF]), PD-L1 (≥ 100 cells/HPF), and PD-L2 (≥ 100 cells/HPF) were determined by the area under the receiver operating characteristic curve. Expression of PD-1, PD-L1, and PD-L2 was high in 7.9%, 13.2%, and 42.1% patients, respectively. High PD-1, (P = 0.007) and Memorial Sloan Kettering Cancer Center (MSKCC) prognostic scoring (P = 0.019) were independently associated with inferior overall survival on multivariate analysis. High PD-1 also remained an independent prognostic factor for inferior progression-free survival (P = 0.028), as did MSKCC prognostic scoring (P = 0.041) on multivariate analysis. However, there were no differences in survival according to the expression levels of PD-L1/PD-L2 in PCNSL tumor microenvironment. Our results suggest that PD-1 may be considered a biomarker and potential therapeutic target in PCNSL.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161365
DOI
10.18632/oncotarget.20264
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
김세훈(Kim, Se Hoon) ; 김수정(Kim, Soo Jeong) ; 김유리(Kim, Yu Ri) ; 김진석(Kim, Jin Seok) ; 민유홍(Min, Yoo Hong) ; 서창옥(Suh, Chang Ok) ; 양우익(Yang, Woo Ick) ; 장종희(Chang, Jong Hee) ; 장지은(Jang, Ji Eun) ; 정준원(Cheong, June-Won)
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