382 665

Cited 24 times in

Programmed cell death 1 expression is associated with inferior survival in patients with primary central nervous system lymphoma

DC Field Value Language
dc.contributor.author김세훈-
dc.contributor.author김수정-
dc.contributor.author김유리-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author서창옥-
dc.contributor.author양우익-
dc.contributor.author장종희-
dc.contributor.author장지은-
dc.contributor.author정준원-
dc.contributor.author조현수-
dc.date.accessioned2018-07-20T08:41:56Z-
dc.date.available2018-07-20T08:41:56Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161365-
dc.description.abstractProgrammed cell death 1 (PD-1) and its ligands PD-L1/PD-L2 have been shown to mediate immune evasion in various cancers, but their prognostic implications in patients with primary central nervous system lymphoma (PCNSL) are poorly understood. Therefore, we analyzed 76 PCNSL patients at initial diagnosis who were treated homogenously with high-dose methotrexate-based chemotherapy, and evaluated the prognostic roles of high immunohistochemical PD-1, PD-L1, and PD-L2 expression. The cut-off values for high PD-1 (≥ 70 cells/high power field [HPF]), PD-L1 (≥ 100 cells/HPF), and PD-L2 (≥ 100 cells/HPF) were determined by the area under the receiver operating characteristic curve. Expression of PD-1, PD-L1, and PD-L2 was high in 7.9%, 13.2%, and 42.1% patients, respectively. High PD-1, (P = 0.007) and Memorial Sloan Kettering Cancer Center (MSKCC) prognostic scoring (P = 0.019) were independently associated with inferior overall survival on multivariate analysis. High PD-1 also remained an independent prognostic factor for inferior progression-free survival (P = 0.028), as did MSKCC prognostic scoring (P = 0.041) on multivariate analysis. However, there were no differences in survival according to the expression levels of PD-L1/PD-L2 in PCNSL tumor microenvironment. Our results suggest that PD-1 may be considered a biomarker and potential therapeutic target in PCNSL.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleProgrammed cell death 1 expression is associated with inferior survival in patients with primary central nervous system lymphoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorHyunsoo Cho-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorSoo-Jeong Kim-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorWoo-Ick Yang-
dc.contributor.googleauthorChang-Ok Suh-
dc.contributor.googleauthorYu Ri Kim-
dc.contributor.googleauthorJi Eun Jang-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorJin Seok Kim-
dc.identifier.doi10.18632/oncotarget.20264-
dc.contributor.localIdA00610-
dc.contributor.localIdA00633-
dc.contributor.localIdA00779-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA01919-
dc.contributor.localIdA02300-
dc.contributor.localIdA03470-
dc.contributor.localIdA03477-
dc.contributor.localIdA03729-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid29152083-
dc.subject.keywordprimary central nervous system lymphoma-
dc.subject.keywordprognosis-
dc.subject.keywordprogrammed cell death 1-
dc.subject.keywordprogrammed cell death-ligand 1-
dc.subject.keywordprogrammed cell death-ligand 2-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameKim, Yu Ri-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameJang, Ji Eun-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorKim, Yu Ri-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorJang, Ji Eun-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.citation.volume8-
dc.citation.number50-
dc.citation.startPage87317-
dc.citation.endPage87328-
dc.identifier.bibliographicCitationONCOTARGET, Vol.8(50) : 87317-87328, 2017-
dc.identifier.rimsid61283-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.