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Does smoking impact dopamine neuronal loss in de novo Parkinson disease?

Authors
 Yoonju Lee  ;  Jungsu S. Oh  ;  Seok Jong Chung  ;  Su Jin Chung  ;  Soo‐Jong Kim  ;  Chung Mo Nam  ;  Phil Hyu Lee  ;  Jae Seung Kim  ;  Young H. Sohn 
Citation
 ANNALS OF NEUROLOGY, Vol.82(5) : 850-854, 2017 
Journal Title
ANNALS OF NEUROLOGY
ISSN
 0364-5134 
Issue Date
2017
MeSH
Aged ; Case-Control Studies ; Corpus Striatum/pathology ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Dopaminergic Neurons/pathology* ; Functional Neuroimaging ; Humans ; Male ; Middle Aged ; Nerve Degeneration/chemically induced* ; Parkinson Disease/pathology* ; Positron-Emission Tomography ; Protective Factors ; Smoking/pathology* ; Tropanes/metabolism
Abstract
This study analyzed data from dopamine transporter (DAT) positron emission tomographic scans of 282 male patients with de novo Parkinson disease to investigate whether smoking impacts striatal dopamine neuronal degeneration. Mean DAT activity in the posterior (p = 0.016) and ventral putamen (p = 0.028) was higher in 44 current smokers in comparison to 105 ex-smokers and 133 never-smokers. The severity of baseline motor deficits and the longitudinal increases in levodopa-equivalent doses during follow-up were similar among the 3 groups. These results suggest that current smoking, but not past smoking, protects dopamine neuronal degeneration in the sensorimotor striatum with no additional clinical benefits.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25082
DOI
10.1002/ana.25082
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Yoon Ju(이윤주)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
Chung, Su Jin(정수진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161350
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