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Cited 5 times in

Does smoking impact dopamine neuronal loss in de novo Parkinson disease?

DC Field Value Language
dc.contributor.author남정모-
dc.contributor.author손영호-
dc.contributor.author이윤주-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.contributor.author정수진-
dc.date.accessioned2018-07-20T08:40:15Z-
dc.date.available2018-07-20T08:40:15Z-
dc.date.issued2017-
dc.identifier.issn0364-5134-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161350-
dc.description.abstractThis study analyzed data from dopamine transporter (DAT) positron emission tomographic scans of 282 male patients with de novo Parkinson disease to investigate whether smoking impacts striatal dopamine neuronal degeneration. Mean DAT activity in the posterior (p = 0.016) and ventral putamen (p = 0.028) was higher in 44 current smokers in comparison to 105 ex-smokers and 133 never-smokers. The severity of baseline motor deficits and the longitudinal increases in levodopa-equivalent doses during follow-up were similar among the 3 groups. These results suggest that current smoking, but not past smoking, protects dopamine neuronal degeneration in the sensorimotor striatum with no additional clinical benefits.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfANNALS OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCorpus Striatum/pathology-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins/metabolism-
dc.subject.MESHDopaminergic Neurons/pathology*-
dc.subject.MESHFunctional Neuroimaging-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNerve Degeneration/chemically induced*-
dc.subject.MESHParkinson Disease/pathology*-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHProtective Factors-
dc.subject.MESHSmoking/pathology*-
dc.subject.MESHTropanes/metabolism-
dc.titleDoes smoking impact dopamine neuronal loss in de novo Parkinson disease?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorYoonju Lee-
dc.contributor.googleauthorJungsu S. Oh-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorSu Jin Chung-
dc.contributor.googleauthorSoo‐Jong Kim-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorJae Seung Kim-
dc.contributor.googleauthorYoung H. Sohn-
dc.identifier.doi10.1002/ana.25082-
dc.contributor.localIdA01264-
dc.contributor.localIdA01982-
dc.contributor.localIdA03024-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.contributor.localIdA04668-
dc.relation.journalcodeJ00166-
dc.identifier.eissn1531-8249-
dc.identifier.pmid29059491-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25082-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Yoon Ju-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameChung, Seok Jong-
dc.contributor.alternativeNameChung, Su Jin-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Yoon Ju-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorChung, Seok Jong-
dc.contributor.affiliatedAuthorChung, Su Jin-
dc.citation.volume82-
dc.citation.number5-
dc.citation.startPage850-
dc.citation.endPage854-
dc.identifier.bibliographicCitationANNALS OF NEUROLOGY, Vol.82(5) : 850-854, 2017-
dc.identifier.rimsid61269-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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