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응급진료센터에 내원한 ST 분절 상승 심근 경색 환자에서 혈소판 용적 지표의 연속 측정을 통한 30일 사망률 예측의 유용성

Other Titles
 Usefulness of Serial Measurement of the Platelet Volume Indices to Predict 30-day Mortality in Patients with ST Segment Elevation Myocardial Infarction 
Authors
 유지나  ;  유제성  ;  정성필  ;  공태영  ;  고동률  ;  김시내  ;  주영선  ;  황윤정  ;  좌민홍  ;  박인철 
Citation
 Journal of the Korean Society of Emergency Medicine (대한응급의학회지), Vol.28(5) : 514-524, 2017 
Journal Title
Journal of the Korean Society of Emergency Medicine(대한응급의학회지)
ISSN
 1226-4334 
Issue Date
2017
Keywords
ST Elevation myocardial infarction ; Mean platelet volume ; Platelet activation ; Prognosis
Abstract
Purpose: Among the survivors of a ST elevation myocardial infarction (STEMI), higher platelet volume indices (mean platelet volume, MPV; platelet distribution width, PDW) are associated with impaired reperfusion and ventricular dysfunction. This study examined the relationship between the platelet volume indices and 30-day mortality with STEMI patients who underwent primary percutaneous coronary intervention (PCI).
Methods: This retrospective cohort study included patients presenting to the emergency department with STEMI
between January 2011 and May 2016. The platelet volume indices were measured serially, using an automatic hematology analyzer, from admission to 24 hours after admission. The prognostic value of MPV, PDW for the 30-day mortality was determined by Cox proportional hazards model analysis.
Results: A total of 608 STEMI patients, who underwent reperfusion, were enrolled in this study. According to the multivariable Cox proportional hazard model, higher MPV (hazard ratio [HR], 1.414; 95% confidence interval [CI], 1.024-1.953; p=0.035) and PDW (HR, 1.043; 95% CI, 1.006-1.083; p=0.024) values at time-24 (24 hours after admission) were significant risk factors for the 30-day mortality. A MPV value >8.6 fL (HR, 5.953; 95% CI, 2.973-11.918; p<0.001) and PDW value >56.1% (HR, 5.117; 95% CI, 2.640-9.918; p<0.001) at time-24 were associated with an increased risk of 30-day mortality.
Conclusion: The platelet volume indices without an additional burden of cost or time, can be measured rapidly and simply. Higher MPV and PDW levels predict independently the 30-day mortality in patients with STEMI after PCI.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Ko, Dong Ryul(고동률) ORCID logo https://orcid.org/0000-0002-3098-2784
Kong, Tae Young(공태영) ORCID logo https://orcid.org/0000-0002-4182-7245
Kim, Si Nae(김시내)
Park, In Cheol(박인철) ORCID logo https://orcid.org/0000-0001-7033-766X
You, Je Sung(유제성) ORCID logo https://orcid.org/0000-0002-2074-6745
Chung, Sung Phil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
Choa, Min Hong(좌민홍) ORCID logo https://orcid.org/0000-0003-0338-994X
Joo, Young Seon(주영선)
Hwang, Yoon Jung(황윤정) ORCID logo https://orcid.org/0000-0001-7286-7699
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161317
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