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Hemorrhagic Transformation After Large Cerebral Infarction in Rats Pretreated With Dabigatran or Warfarin

DC FieldValueLanguage
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author백장현-
dc.contributor.author유준상-
dc.contributor.author이혜선-
dc.contributor.author허지회-
dc.contributor.author최현정-
dc.date.accessioned2018-07-20T08:27:16Z-
dc.date.available2018-07-20T08:27:16Z-
dc.date.issued2017-
dc.identifier.issn0039-2499-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161207-
dc.description.abstractBACKGROUND AND PURPOSE: It is uncertain whether hemorrhagic transformation (HT) after large cerebral infarction is less frequent in dabigatran users than warfarin users. We compared the occurrence of HT after large cerebral infarction among rats pretreated with dabigatran, warfarin, or placebo. METHODS: This was a triple-blind, randomized, and placebo-controlled experiment. After treatment with warfarin (0.2 mg/kg), dabigatran (20 mg/kg), or saline for 7 days, Wistar rats were subjected to transient middle cerebral artery occlusion. As the primary outcome, HT was determined by gradient-recalled echo imaging. For the secondary outcome, intracranial hemorrhage was assessed via gradient-recalled echo imaging in surviving rats and via autopsy for dead rats. RESULTS: Of 62 rats, there were 33 deaths (53.2%, 17 technical reasons). Of the intention-to-treat population, 33 rats underwent brain imaging. HT was less frequent in the dabigatran group than the warfarin group (placebo 2/14 [14%], dabigatran 0/10 [0%], and warfarin 9/9 [100%]; dabigatran versus warfarin; P<0.001). In all 62 rats, compared with the placebo (2/14 [14.3%]), the incidence of intracranial hemorrhage was significantly higher in the warfarin group (19/29 [65.5%]; P=0.003), but not in the dabigatran group (6/19 [31.6%]; P=0.420). Mortality was significantly higher in the warfarin group than the dabigatran group (79.3% versus 47.4%; P=0.022), but not related to the hemorrhage frequency. CONCLUSIONS: The risk of HT after a large cerebral infarction was significantly increased in rats pretreated with warfarin than those with dabigatran. However, the results here may not have an exact clinical translation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfStroke-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAnticoagulants/administration & dosage-
dc.subject.MESHAntithrombins/administration & dosage-
dc.subject.MESHCerebral Infarction/diagnostic imaging*-
dc.subject.MESHCerebral Infarction/drug therapy*-
dc.subject.MESHDabigatran/administration & dosage*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHIntracranial Hemorrhages/diagnostic imaging*-
dc.subject.MESHIntracranial Hemorrhages/drug therapy*-
dc.subject.MESHMale-
dc.subject.MESHRandom Allocation-
dc.subject.MESHRats-
dc.subject.MESHRats, Wistar-
dc.subject.MESHWarfarin/administration & dosage*-
dc.titleHemorrhagic Transformation After Large Cerebral Infarction in Rats Pretreated With Dabigatran or Warfarin-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorIl Kwon-
dc.contributor.googleauthorSunho An-
dc.contributor.googleauthorJayoung Kim-
dc.contributor.googleauthorSeung-Hee Yang-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorJang-Hyun Baek-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorHyun-Jung Choi-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.1161/STROKEAHA.117.017751-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA01834-
dc.contributor.localIdA02513-
dc.contributor.localIdA03312-
dc.contributor.localIdA04369-
dc.contributor.localIdA04211-
dc.relation.journalcodeJ02690-
dc.identifier.eissn1524-4628-
dc.identifier.pmid28904233-
dc.identifier.urlhttp://stroke.ahajournals.org/content/48/10/2865.long-
dc.subject.keywordanticoagulants-
dc.subject.keywordcerebral hemorrhage-
dc.subject.keywordcerebral infarction-
dc.subject.keyworddabigatran-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keywordstroke-
dc.subject.keywordwarfarin-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameBaek, Jang Hyun-
dc.contributor.alternativeNameYoo, Joon Sang-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorBaek, Jang Hyun-
dc.contributor.affiliatedAuthorYoo, Joon Sang-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.contributor.affiliatedAuthorChoi, Hyun-Jung-
dc.citation.volume48-
dc.citation.number10-
dc.citation.startPage2865-
dc.citation.endPage2871-
dc.identifier.bibliographicCitationStroke, Vol.48(10) : 2865-2871, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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