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Gender Difference in the Prognostic Value of N-Terminal Pro-B Type Natriuretic Peptide in Patients With Heart Failure - A Report From the Korean Heart Failure Registry (KorHF)

Authors
 Hack-Lyoung Kim  ;  Myung-A Kim  ;  Dong-Ju Choi  ;  Seongwoo Han  ;  Eun-Seok Jeon  ;  Myeong-Chan Cho  ;  Jae-Joong Kim  ;  Byung-Su Yoo  ;  Mi-Seung Shin  ;  In-Whan Seong  ;  Youngkeun Ahn  ;  Seok-Min Kang  ;  Young-Jo Kim  ;  Hyung Seop Kim  ;  Shung Chull Chae  ;  Byung-Hee Oh  ;  Myoung-Mook Lee  ;  Kyu-Hyung Ryu 
Citation
 CIRCULATION JOURNAL, Vol.81(9) : 1329-1336, 2017 
Journal Title
CIRCULATION JOURNAL
ISSN
 1346-9843 
Issue Date
2017
Keywords
Gender ; Heart failure ; N-terminal pro-B type natriuretic peptide ; Prognosis
Abstract
BACKGROUND: Very little data is available to evaluate the gender-specific role of N-terminal pro-B type natriuretic peptide (NT-proBNP). This study was performed to investigate whether there is a gender difference in the prognostic value of NT-proBNP in patients hospitalized for heart failure (HF).Methods and Results:A total of 2,280 patients hospitalized with HF (67.9±14.3 years, 50.9% women) from the nationwide registry database were analyzed. Composite events including all-cause mortality and HF readmission were assessed. During the mean follow-up period of 1,245±824 days, there were 1,067 cases of composite events (49.7%). NT-proBNP levels were significantly higher in patients with events than those without in both genders (P<0.001 for each). A higher NT-proBNP level was an independent predictor of events (highest vs. lowest tertile: hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.25-2.43; P=0.001) in men, even after controlling for potential confounders. However, NT-proBNP was not associated with the occurrence of composite events in women in the same multivariable analysis (P>0.05).

CONCLUSIONS: In patients with HF, the NT-proBNP level seems to be a more valuable marker in the prediction of long-term mortality and HF readmission in men than in women.
Files in This Item:
T201704191.pdf Download
DOI
10.1253/circj.CJ-16-1345
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161152
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