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Accurate assessment of alpha-gal syndrome using cetuximab and bovine thyroglobulin-specific IgE

Authors
 Da Woon Sim  ;  Jong Sun Lee  ;  Kyung Hee Park  ;  Kyoung Yong Jeong  ;  Young‐Min Ye  ;  Jae‐Hyun Lee  ;  Jung‐Won Park 
Citation
 Molecular Nutrition & Food Research, Vol.61(10) : 1-11, 2017 
Journal Title
 Molecular Nutrition & Food Research 
ISSN
 1613-4125 
Issue Date
2017
Keywords
Alpha-gal syndrome ; Bovine thyroglobulin-specific IgE ; Cetuximab-specific IgE ; Component-resolved diagnosis ; α-Gal
Abstract
SCOPE: IgE against galactose-α-1,3-galactose (α-Gal) causes alpha-gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against cetuximab as compared to BTG for diagnosing alpha-gal syndrome. METHODS AND RESULTS: Twelve patients with alpha-gal syndrome, 11 patients with immediate beef or pork allergy, 18 asymptomatic individuals with meat sensitization, and 10 non-atopic subjects were enrolled. We checked the levels of sIgE against BTG and cetuximab using the streptavidin CAP assay. Additionally, IgE reactivity to BTG and cetuximab was assessed by immunoblotting. All alpha-gal syndrome patients had a high concentration of sIgE against BTG, and cetuximab. In contrast to alpha-gal syndrome, patients with immediate allergic reactions to meat consumption and those with asymptomatic sensitization had significantly lower concentration of BTG and cetuximab sIgE, and a high prevalence of sIgE against bovine or porcine serum albumin. Although the concentration of sIgE against alpha-gal was lower in individuals with asymptomatic sensitization, IgE immunoblotting showed the presence of sIgE against α-Gal in this group. CONCLUSION: Differentiation of alpha-gal syndrome from patients with immediate allergy to meat consumption or asymptomatic sensitization requires quantification of cetuximab- or BTG-induced sIgE via detection of IgE for α-gal.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161099
DOI
10.1002/mnfr.201601046
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소)
Yonsei Authors
박경희(Park, Kyung Hee) ; 박중원(Park, Jung Won) ; 심다운(Sim, Da Woon) ; 이재현(Lee, Jae Hyun) ; 정경용(Jeong, Kyoung Yong)
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Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201601046
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