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Accurate assessment of alpha-gal syndrome using cetuximab and bovine thyroglobulin-specific IgE

Authors
 Da Woon Sim  ;  Jong Sun Lee  ;  Kyung Hee Park  ;  Kyoung Yong Jeong  ;  Young‐Min Ye  ;  Jae‐Hyun Lee  ;  Jung‐Won Park 
Citation
 MOLECULAR NUTRITION & FOOD RESEARCH, Vol.61(10) : 1-11, 2017 
Journal Title
MOLECULAR NUTRITION & FOOD RESEARCH
ISSN
 1613-4125 
Issue Date
2017
Keywords
Alpha-gal syndrome ; Bovine thyroglobulin-specific IgE ; Cetuximab-specific IgE ; Component-resolved diagnosis ; α-Gal
Abstract
SCOPE:

IgE against galactose-α-1,3-galactose (α-Gal) causes alpha-gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against cetuximab as compared to BTG for diagnosing alpha-gal syndrome.

METHODS AND RESULTS:

Twelve patients with alpha-gal syndrome, 11 patients with immediate beef or pork allergy, 18 asymptomatic individuals with meat sensitization, and 10 non-atopic subjects were enrolled. We checked the levels of sIgE against BTG and cetuximab using the streptavidin CAP assay. Additionally, IgE reactivity to BTG and cetuximab was assessed by immunoblotting. All alpha-gal syndrome patients had a high concentration of sIgE against BTG, and cetuximab. In contrast to alpha-gal syndrome, patients with immediate allergic reactions to meat consumption and those with asymptomatic sensitization had significantly lower concentration of BTG and cetuximab sIgE, and a high prevalence of sIgE against bovine or porcine serum albumin. Although the concentration of sIgE against alpha-gal was lower in individuals with asymptomatic sensitization, IgE immunoblotting showed the presence of sIgE against α-Gal in this group.

CONCLUSION:

Differentiation of alpha-gal syndrome from patients with immediate allergy to meat consumption or asymptomatic sensitization requires quantification of cetuximab- or BTG-induced sIgE via detection of IgE for α-gal.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201601046
DOI
10.1002/mnfr.201601046
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Hee(박경희) ORCID logo https://orcid.org/0000-0003-3605-5364
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Sim, Da Woon(심다운)
Lee, Jae Hyun(이재현) ORCID logo https://orcid.org/0000-0002-0760-0071
Jeong, Kyoung Yong(정경용) ORCID logo https://orcid.org/0000-0001-9887-1426
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161099
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