0 76

Cited 4 times in

Accurate assessment of alpha-gal syndrome using cetuximab and bovine thyroglobulin-specific IgE

DC FieldValueLanguage
dc.contributor.author박경희-
dc.contributor.author박중원-
dc.contributor.author심다운-
dc.contributor.author이재현-
dc.contributor.author정경용-
dc.date.accessioned2018-07-20T08:20:01Z-
dc.date.available2018-07-20T08:20:01Z-
dc.date.issued2017-
dc.identifier.issn1613-4125-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161099-
dc.description.abstractSCOPE: IgE against galactose-α-1,3-galactose (α-Gal) causes alpha-gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against cetuximab as compared to BTG for diagnosing alpha-gal syndrome. METHODS AND RESULTS: Twelve patients with alpha-gal syndrome, 11 patients with immediate beef or pork allergy, 18 asymptomatic individuals with meat sensitization, and 10 non-atopic subjects were enrolled. We checked the levels of sIgE against BTG and cetuximab using the streptavidin CAP assay. Additionally, IgE reactivity to BTG and cetuximab was assessed by immunoblotting. All alpha-gal syndrome patients had a high concentration of sIgE against BTG, and cetuximab. In contrast to alpha-gal syndrome, patients with immediate allergic reactions to meat consumption and those with asymptomatic sensitization had significantly lower concentration of BTG and cetuximab sIgE, and a high prevalence of sIgE against bovine or porcine serum albumin. Although the concentration of sIgE against alpha-gal was lower in individuals with asymptomatic sensitization, IgE immunoblotting showed the presence of sIgE against α-Gal in this group. CONCLUSION: Differentiation of alpha-gal syndrome from patients with immediate allergy to meat consumption or asymptomatic sensitization requires quantification of cetuximab- or BTG-induced sIgE via detection of IgE for α-gal.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-VCH-
dc.relation.isPartOfMolecular Nutrition & Food Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAccurate assessment of alpha-gal syndrome using cetuximab and bovine thyroglobulin-specific IgE-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDa Woon Sim-
dc.contributor.googleauthorJong Sun Lee-
dc.contributor.googleauthorKyung Hee Park-
dc.contributor.googleauthorKyoung Yong Jeong-
dc.contributor.googleauthorYoung‐Min Ye-
dc.contributor.googleauthorJae‐Hyun Lee-
dc.contributor.googleauthorJung‐Won Park-
dc.identifier.doi10.1002/mnfr.201601046-
dc.contributor.localIdA01427-
dc.contributor.localIdA01681-
dc.contributor.localIdA04598-
dc.contributor.localIdA03086-
dc.contributor.localIdA03572-
dc.relation.journalcodeJ02264-
dc.identifier.eissn1613-4133-
dc.identifier.pmid28497612-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201601046-
dc.subject.keywordAlpha-gal syndrome-
dc.subject.keywordBovine thyroglobulin-specific IgE-
dc.subject.keywordCetuximab-specific IgE-
dc.subject.keywordComponent-resolved diagnosis-
dc.subject.keywordα-Gal-
dc.contributor.alternativeNamePark, Kyung Hee-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNameSim, Da Woon-
dc.contributor.alternativeNameLee, Jae Hyun-
dc.contributor.alternativeNameJeong, Kyoung Yong-
dc.contributor.affiliatedAuthorPark, Kyung Hee-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorSim, Da Woon-
dc.contributor.affiliatedAuthorLee, Jae Hyun-
dc.contributor.affiliatedAuthorJeong, Kyoung Yong-
dc.citation.volume61-
dc.citation.number10-
dc.citation.startPage1-
dc.citation.endPage11-
dc.identifier.bibliographicCitationMolecular Nutrition & Food Research, Vol.61(10) : 1-11, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.