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Changes in Serum IgA Antibody Levels against the Glycopeptidolipid Core Antigen during Antibiotic Treatment of Mycobacterium avium Complex Lung Disease

 Byung Woo Jhun  ;  Su-Young Kim  ;  Hye Yun Park  ;  Kyeongman Jeon  ;  Sung Jae Shin  ;  Won-Jung Koh 
 Japanese Journal of Infectious Diseases, Vol.70(5) : 582-585, 2017 
Journal Title
 Japanese Journal of Infectious Diseases 
Issue Date
Aged ; Anti-Bacterial Agents/therapeutic use* ; Antibodies, Bacterial/blood* ; Antigens, Bacterial/immunology* ; Female ; Glycoconjugates/immunology ; Humans ; Immunoglobulin A/blood* ; Lung Diseases/drug therapy ; Lung Diseases/immunology ; Male ; Middle Aged ; Mycobacterium avium Complex/immunology* ; Mycobacterium avium-intracellulare Infection/drug therapy* ; Mycobacterium avium-intracellulare Infection/immunology* ; Treatment Outcome
Mycobacterium avium complex ; glycopeptidolipid ; immunoenzyme techniques ; serologic tests ; treatment outcome
We evaluated serial changes in the levels of serum immunoglobulin A (IgA) antibody to the glycopeptidolipid (GPL) core antigen during antibiotic treatment in 57 patients with Mycobacterium avium complex (MAC) lung disease at baseline (T0) and after 3 months (T3) and 6 months (T6) of treatment. The median patient age was 59 years, and 37 (65%) patients were women. The etiologic organisms included M. avium in 32 (56%) patients and M. intracellulare in 25 (44%) patients. Seven (12%) patients had the fibrocavitary form of the disease on computed tomography. After 12 months of treatment, 42 (74%) patients had a favorable response to treatment, whereas 15 (26%) patients had an unfavorable response to treatment defined as the absence of sputum culture conversion within 12 months of treatment. The initial median serum anti-GPL IgA levels in the 57 patients was 3.50 U/mL, and the antibody levels at T0 (median 3.50 U/mL), T3 (median 2.71 U/mL), and T6 (median 2.61 U/mL) were significantly decreased following treatment (P < 0.001). The results of the multivariate analysis indicated that an initially elevated anti-GPL IgA level (> 3.50 U/mL) was associated with an unfavorable response (P = 0.049). Our data suggest that elevated anti-GPL IgA levels may reflect disease activity and may help predict treatment response in patients with MAC lung disease.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
신성재(Shin, Sung Jae)
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