Cited 10 times in
Changes in Serum IgA Antibody Levels against the Glycopeptidolipid Core Antigen during Antibiotic Treatment of Mycobacterium avium Complex Lung Disease
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2018-07-20T08:19:06Z | - |
dc.date.available | 2018-07-20T08:19:06Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1344-6304 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161086 | - |
dc.description.abstract | We evaluated serial changes in the levels of serum immunoglobulin A (IgA) antibody to the glycopeptidolipid (GPL) core antigen during antibiotic treatment in 57 patients with Mycobacterium avium complex (MAC) lung disease at baseline (T0) and after 3 months (T3) and 6 months (T6) of treatment. The median patient age was 59 years, and 37 (65%) patients were women. The etiologic organisms included M. avium in 32 (56%) patients and M. intracellulare in 25 (44%) patients. Seven (12%) patients had the fibrocavitary form of the disease on computed tomography. After 12 months of treatment, 42 (74%) patients had a favorable response to treatment, whereas 15 (26%) patients had an unfavorable response to treatment defined as the absence of sputum culture conversion within 12 months of treatment. The initial median serum anti-GPL IgA levels in the 57 patients was 3.50 U/mL, and the antibody levels at T0 (median 3.50 U/mL), T3 (median 2.71 U/mL), and T6 (median 2.61 U/mL) were significantly decreased following treatment (P < 0.001). The results of the multivariate analysis indicated that an initially elevated anti-GPL IgA level (> 3.50 U/mL) was associated with an unfavorable response (P = 0.049). Our data suggest that elevated anti-GPL IgA levels may reflect disease activity and may help predict treatment response in patients with MAC lung disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | National Institute of Infectious Diseases | - |
dc.relation.isPartOf | JAPANESE JOURNAL OF INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Bacterial Agents/therapeutic use* | - |
dc.subject.MESH | Antibodies, Bacterial/blood* | - |
dc.subject.MESH | Antigens, Bacterial/immunology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycoconjugates/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin A/blood* | - |
dc.subject.MESH | Lung Diseases/drug therapy | - |
dc.subject.MESH | Lung Diseases/immunology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium avium Complex/immunology* | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection/drug therapy* | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection/immunology* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Changes in Serum IgA Antibody Levels against the Glycopeptidolipid Core Antigen during Antibiotic Treatment of Mycobacterium avium Complex Lung Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Byung Woo Jhun | - |
dc.contributor.googleauthor | Su-Young Kim | - |
dc.contributor.googleauthor | Hye Yun Park | - |
dc.contributor.googleauthor | Kyeongman Jeon | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Won-Jung Koh | - |
dc.identifier.doi | 10.7883/yoken.JJID.2016.523 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01208 | - |
dc.identifier.eissn | 1884-2836 | - |
dc.identifier.pmid | 28367886 | - |
dc.subject.keyword | Mycobacterium avium complex | - |
dc.subject.keyword | glycopeptidolipid | - |
dc.subject.keyword | immunoenzyme techniques | - |
dc.subject.keyword | serologic tests | - |
dc.subject.keyword | treatment outcome | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 70 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 582 | - |
dc.citation.endPage | 585 | - |
dc.identifier.bibliographicCitation | JAPANESE JOURNAL OF INFECTIOUS DISEASES, Vol.70(5) : 582-585, 2017 | - |
dc.identifier.rimsid | 60976 | - |
dc.type.rims | ART | - |
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