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Aberrant expression of OATP1B3 in colorectal cancer liver metastases and its clinical implication on gadoxetic acid-enhanced MRI

Authors
 Seung Hyun Park  ;  Honsoul Kim  ;  Eun Kyung Kim  ;  Hogeun Kim  ;  Dong Kyu Choi  ;  Yong Eun Chung  ;  Myeong-Jin Kim  ;  Jin-Young Choi 
Citation
 Oncotarget, Vol.8(41) : 71012-71023, 2017 
Journal Title
 Oncotarget 
Issue Date
2017
Keywords
colorectal cancer (CRC) ; gadoxetic acid (Gd-EOB-DTPA) ; liver metastases (LM) ; magnetic resonance imaging (MRI) ; organic anionic transporting polypeptide (OATP)
Abstract
PURPOSE: To investigate the factors associated with hepatobiliary phase (HBP) enhancement at gadoxetic acid-enhanced magnetic resonance imaging (MRI) and to determine whether HBP images could be used to predict prognosis in patients with colorectal cancer liver metastasis (CRLM). RESULTS: Of the 96 total nodules, 65 and 31 nodules were in the mixed and clearly hypointense groups, respectively. In the 55 nodules without preoperative chemotherapy, organic anionic transporting polypeptide 1B3 (OATP1B3) expression was a significant factor regarding the HBP enhancement (P=0.042). In this subgroup, nodules with OATP1B3 expression displayed a significantly higher relative intensity ratio on the HBP image (RIRpost) and relative enhancement ratio (RER) than those lacking this marker (P=0.024, 0.003, respectively). No significant factor was associated with the enhancement pattern in the chemotherapy group. The mixed hypointense group displayed worse survival rates (P=0.002). MATERIALS AND METHODS: Ninety-six patients who underwent pre-operative liver MRI and surgical resection for CRLM from January 2010 to June 2012 were retrospectively analyzed. We qualitatively evaluated the HBP enhancement pattern of CRLMs and classified them into mixed and clearly hypointense groups. For quantitative measurement, the RIRpost and RER were analyzed. To investigate factors associated with HBP enhancement, tumor components (fibrosis, necrosis, and cellularity) and OATP1B3 expression were scored on a 4-point scale. Univariate and multivariate analyses were done to determine significant factors for visual enhancement and quantitative parameters. CONCLUSIONS: OATP1B3 expression is associated with mixed hypointense CRLMs without chemotherapy. Signal intensity on HBP has potential usefulness to predict prognosis in CRLMs.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161018
DOI
10.18632/oncotarget.20295
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김명진(Kim, Myeong Jin)
김은경(Kim, Eun Kyung)
김한솔(Kim, Hon Soul)
김호근(Kim, Ho Keun)
박승현(Park, Seung Hyun)
정용은(Chung, Yong Eun)
최진영(Choi, Jin Young)
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