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Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells

Authors
 Hye-Yeon Lee  ;  Juri Kim  ;  Jae-Sook Ryu  ;  Soon-Jung Park 
Citation
 Korean Journal of Parasitology, Vol.55(4) : 375-384, 2017 
Journal Title
 Korean Journal of Parasitology 
ISSN
 0023-4001 
Issue Date
2017
MeSH
Actinin/immunology* ; Animals ; Antibodies, Protozoan/immunology ; Cells, Cultured ; Dendritic Cells/immunology* ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells/immunology ; Host-Parasite Interactions/immunology* ; Humans ; Interleukin-10/biosynthesis* ; Mice, Inbred BALB C ; Organic Chemicals/immunology ; T-Lymphocytes, Regulatory/immunology* ; Trichomonas vaginalis/immunology*
Keywords
Treg cell ; Trichomonas vaginalis ; interleukin-10 (IL-10) ; α-actinin 2
Abstract
Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis α-actinin 2, Tvα-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tvα-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tvα-actinin 2 antibodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tvα-actinin 2 protein. Both T. vaginalis and rTvα-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4+CD25- regulatory T cells (Treg cells) incubated with rTvα-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tvα-actinin 2 modulates immune responses via IL-10 production by Treg cells.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160991
DOI
10.3347/kjp.2017.55.4.375
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실)
Yonsei Authors
김주리(Kim, Ju Ri)
박순정(Park, Soon Jung)
이혜연(Lee, Hye Yeon)
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