Cited 7 times in
Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells
DC Field | Value | Language |
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dc.contributor.author | 김주리 | - |
dc.contributor.author | 박순정 | - |
dc.contributor.author | 이혜연 | - |
dc.date.accessioned | 2018-07-20T08:13:50Z | - |
dc.date.available | 2018-07-20T08:13:50Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160991 | - |
dc.description.abstract | Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis α-actinin 2, Tvα-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tvα-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tvα-actinin 2 antibodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tvα-actinin 2 protein. Both T. vaginalis and rTvα-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4+CD25- regulatory T cells (Treg cells) incubated with rTvα-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tvα-actinin 2 modulates immune responses via IL-10 production by Treg cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society for Parasitology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Actinin/immunology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Protozoan/immunology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dendritic Cells/immunology* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Epithelial Cells/immunology | - |
dc.subject.MESH | Host-Parasite Interactions/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-10/biosynthesis* | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Organic Chemicals/immunology | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/immunology* | - |
dc.subject.MESH | Trichomonas vaginalis/immunology* | - |
dc.title | Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Environmental Medical Biology | - |
dc.contributor.googleauthor | Hye-Yeon Lee | - |
dc.contributor.googleauthor | Juri Kim | - |
dc.contributor.googleauthor | Jae-Sook Ryu | - |
dc.contributor.googleauthor | Soon-Jung Park | - |
dc.identifier.doi | 10.3347/kjp.2017.55.4.375 | - |
dc.contributor.localId | A00933 | - |
dc.contributor.localId | A01545 | - |
dc.contributor.localId | A03314 | - |
dc.relation.journalcode | J01957 | - |
dc.identifier.eissn | 1738-0006 | - |
dc.identifier.pmid | 28877568 | - |
dc.subject.keyword | Treg cell | - |
dc.subject.keyword | Trichomonas vaginalis | - |
dc.subject.keyword | interleukin-10 (IL-10) | - |
dc.subject.keyword | α-actinin 2 | - |
dc.contributor.alternativeName | Kim, Ju Ri | - |
dc.contributor.alternativeName | Park, Soon Jung | - |
dc.contributor.alternativeName | Lee, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Ju Ri | - |
dc.contributor.affiliatedAuthor | Park, Soon Jung | - |
dc.contributor.affiliatedAuthor | Lee, Hye Yeon | - |
dc.citation.volume | 55 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 375 | - |
dc.citation.endPage | 384 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, Vol.55(4) : 375-384, 2017 | - |
dc.identifier.rimsid | 60883 | - |
dc.type.rims | ART | - |
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