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Dementia-Predicting Cognitive Risk Score and Its Correlation with Cortical Thickness in Parkinson Disease

Authors
 Ye B.S.  ;  Jeon S.  ;  Ham J.H.  ;  Lee J.J.  ;  Lee J.M.  ;  Lee H.S.  ;  Lee P.H.  ;  Sohn Y.H. 
Citation
 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, Vol.44(3~4) : 203-212, 2017 
Journal Title
 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 
ISSN
 1420-8008 
Issue Date
2017
Abstract
BACKGROUND: We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. METHODS: A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk. Then, a multivariate Cox regression model combined them into a cognitive risk score system. Cortical areas correlating with cognitive risk score were investigated using a separate MRI data set from 207 nondemented PD patients. RESULTS: Fifty-two patients (23.9%) developed dementia. The univariate Cox regression analyses identified the confrontational naming and semantic fluency tests, frontal/executive function tests, immediate verbal memory test, and visuospatial function test as predicting dementia risk. The calculated cognitive risk score (range 53-188) predicted future dementia with moderate accuracy (integrated area under the curve = 0.79; 95% CI: 0.73-0.85). A higher cognitive risk score correlated with cortical thinning in the right anteromedial temporal cortex, bilateral posterior cingulate cortex, right anterior cingulate cortex, left parahippocampal gyrus, and right superior frontal cortex in a separate MRI data set. CONCLUSION: The cognitive risk score system is a useful approach to predict the dementia risk among PD patients.
Full Text
https://www.karger.com/Article/Abstract/479057
DOI
10.1159/000479057
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Ham, Jee Hyun(함지현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160979
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