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SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development

Authors
 Tomoko Sagai  ;  Takanori Amano  ;  Akiteru Maeno  ;  Hiroshi Kiyonari  ;  Hyejin Seo  ;  Sung-Won Cho  ;  Toshihiko Shiroishi 
Citation
 Scientific Reports, Vol.7(1) : 13004, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
Interaction between the epithelium and mesenchyme coordinates patterning and differentiation of oral cavity structures including teeth, palatal rugae and tongue papillae. SHH is one of the key signaling molecules for this interaction. Epithelial expression of Shh in the tooth buds and tongue papillae is regulated by at least two enhancers, MRCS1 and MFCS4. However, it is unclear how the two enhancers cooperate to regulate Shh. Here, we found that simultaneous deletion of MRCS1 and MFCS4 results in the formation of a supernumerary tooth in front of the first molar. Since deletion of either single enhancer barely affects tooth development, MRCS1 and MFCS4 evidently act in a redundant fashion. Binding motifs for WNT signaling mediators are shared by MRCS1 and MFCS4, and play a central role in regulating Shh expression, indicating that the two redundant enhancers additively exert their Shh regulation by responding to WNT signal input.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160978
DOI
10.1038/s41598-017-12532-y
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
Yonsei Authors
조성원(Cho, Sung Won)
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